• Effect of Acupuncture on Psychoneurological Symptom Cluster in Breast Cancer Survivors

  NCT07481903

  Not yet recruitingInterventionalNot ApplicableUpdated Mar 19, 2026
• Electroacupuncture Therapy in Reducing Chronic Pain in Patients After Breast Cancer Treatment

  NCT02754752

  Active, not recruitingInterventionalPhase 2Updated Apr 15, 2026
• S1200: Acupuncture, Sham Acupuncture, or Wait List for Joint Symptoms Related to Aromatase Inhibitors in Pts W/Early-Stage Breast Cancer

  NCT01535066

  CompletedInterventionalNot ApplicableUpdated Dec 7, 2022
• Acupuncture for Joint Symptoms in Patients With Breast Cancer

  NCT03836872

  TerminatedInterventionalNot ApplicableUpdated Aug 25, 2022
• PEACE: Comparing Chronic Pain Treatment Options

  NCT02979574

  Active, not recruitingInterventionalNot ApplicableUpdated Dec 4, 2025
• Study on the Impact of Electroacupuncture Combined With Self-Acupressure on the Quality of Life of Patients With Early-Stage Breast Cancer Undergoing Chemotherapy

  NCT06601621

  RecruitingInterventionalNot ApplicableUpdated Feb 12, 2026

ClinicalTrials.gov ID

NCT07490938

Lead Sponsor

First Teaching Hospital of Tianjin University of Traditional Chinese MedicineOTHER

Overall Status

Not yet recruiting

Study Type

Interventional

Phase

Not Applicable

Enrollment

200Estimated

Last Update Posted

Apr 6, 2026Actual

Start Date

Apr 2026Estimated

Primary Completion Date

Oct 2027Estimated

Completion Date

Dec 2027Estimated

Official Title

Electroacupuncture Versus Auricular Acupressure Versus WaitliSt Control for Endocrine Therapy-related Joint Pain in Patients With Breast Cancer (EASE): A Pragmatic Multicenter Randomised Controlled Trial

Brief Summary

The purpose of this pragmatic, multicenter, randomized controlled trial is to evaluate the clinical effectiveness and safety of electroacupuncture and auricular acupressure for improving joint pain related to endocrine therapy in breast cancer patients. A total of 200 participants will be recruited and randomly assigned to one of three groups: the Electroacupuncture Group (n=80), the Auricular Acupressure Group (n=80), or the Waitlist Control Group (n=40), using a central stratified block randomization method.

The primary objective is to compare changes in Worst Pain Item score among the three groups from baseline to the end of the treatment period, as measured by the Brief Pain Inventory-Short Form (BPI-SF). Secondary objectives include assessing pain interference, overall health status through the PROMIS scale, and quality of life specifically related to endocrine therapy using the FACT-ES. Additionally, the study will evaluate analgesic medication use (QAQ), patient expectations (Acupuncture Expectancy Scale), treatment adherence, and the occurrence of adverse events. By comparing these interventions, this study aims to generate high-quality evidence for the management of treatment-related arthralgia in breast cancer survivors.

• Breast Cancer Survivors
• Endocrine Therapy-Induced Joint Pain

• Electroacupuncture Group
• Auricular Acupressure Group

Ages Eligible for Study

Adult (18-64)Older Adult (65+)

Sexes Eligible for Study

Female

Accepts Healthy Volunteers

No

Eligibility Criteria

Inclusion Criteria:

• Histologically or cytologically confirmed breast cancer, stage I-IV, according to the AJCC Cancer Staging Manual (8th edition);
• Aged 18-75 years;
• Experiencing joint pain attributed to endocrine therapy, including localized or generalized joint pain, with symptoms persisting for at least 1 week;
• Completion of all planned surgeries, chemotherapy, and radiotherapy, with a scheduled continuation of endocrine therapy for at least 1 additional year;
• Self-reported worst joint pain score of ≥3 on a 0-10 Visual Analogue Scale (VAS) during the past week;
• Life expectancy ≥1 year;
• Voluntarily sign the informed consent.

Exclusion Criteria:

• Bone metastases involving the same site as the affected joint attributed to endocrine therapy;
• History of fracture or surgery involving the affected joints within the past 6 months;
• Implanted electronic medical devices;
• Not suitable for acupuncture, including but not limited to bleeding tendencies (e.g. coagulation disorders or purpura) or local skin lesions at the intended acupoint sites.

Primary Purpose

Treatment

Allocation

Randomized

Interventional Model

Parallel Assignment

Masking

Single

Lead Sponsor

First Teaching Hospital of Tianjin University of Traditional Chinese MedicineOTHER

wangmiaozhou@163.com86+18609780037