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A comparison of postoperative pain levels, patient satisfaction, and side effects is planned between patients who received morphine during spinal anesthesia for cesarean section and patients who did not receive morphine but underwent bilateral transverse fascial plane block.
It is known that cesarean deliveries are increasingly performed worldwide today. Cesarean operations can cause severe postoperative pain; inadequate control of this pain can lead to negative outcomes such as increased opioid requirements, delayed recovery, chronic pain syndrome, and postpartum depression . Furthermore, inadequate pain control may limit the mother's ability to care for her newborn, negatively affecting mother-newborn interaction, reducing breastfeeding success, and weakening the mother-baby bond.
The ideal analgesic approach should include agents that do not affect the mother's functions and have minimal transfer into breast milk. In this regard, current guidelines recommend multimodal analgesia protocols that include the use of neuraxial local anesthetics and opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), and paracetamol . Although morphine administered via the neuraxial route can provide effective analgesia for the first 12-24 hours postoperatively, its use may be limited due to undesirable side effects such as delayed respiratory depression, nausea, vomiting, and pruritus . For these reasons, alternative methods aimed at reducing opioid use have come to the fore in recent years. Fascial plane blocks performed under ultrasound guidance are recommended as a complementary part of multimodal analgesia in situations where neuroaxial opioids are not used or where analgesia control is inadequate. First described by Hebbard in 2009, the Transverse Fascial Plane Block (TFPB) provides analgesia by targeting the proximal branches of the T12 and L1 nerves between the transversus abdominis muscle and the transverse fascia. TFPB is used to relieve postoperative pain, particularly after lower abdominal surgeries, cesarean sections, and appendectomies.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| intrathecal morphine, transversalis fascia plane block |
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| Measure | Description | Time Frame |
|---|---|---|
| Pain intensity assessed by Numeric Rating Scale (NRS) | Pain intensity, will be assessed using the Numeric Rating Scale ("0" no pain, "10" most severe pain experienced) at rest and during movement (passive flexion of the legs). | 2nd, 6th, 12th, and 24th hours postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| 1. Time to first opioid request | Time from the end of surgery to the first postoperative opioid request, recorded in hours | First 24 hours postoperatively |
| 2. Sedation Level | Postoperative sedation level will be assessed at 2nd, 6th, 12th and 24 hours using Ramsay Sedation Scale (RSS) (1 = anxious or agitated, 2 = cooperative and oriented, 3 = responds to commands only, 4 = brisk responde to stimulus, 5 = sluggish response, 6 = no response) |
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Inclusion Criteria:
Exclusion Criteria:
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Patient who underwent cesarean section under spinal anesthesia
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| Name | Affiliation | Role |
|---|---|---|
| BETÜL YILMAZ, Specialist medical doctor | Vezirkopru State Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Vezirköprü State Hospital | Samsun | Vezirköprü | Turkey (Türkiye) | |||
| Vezirköprü State Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37303881 | Background | Nair A, Dudhedia U, Rangaiah M, Borkar N. Ultrasound-guided transversalis fascia plane block for postoperative analgesia: A systematic review and meta-analysis. Indian J Anaesth. 2023 Apr;67(4):331-342. doi: 10.4103/ija.ija_43_23. Epub 2023 Apr 10. | |
| 33761894 | Background | Pangthipampai P, Dejarkom S, Poolsuppasit S, Luansritisakul C, Tangchittam S. Bilateral posterior Quadratus Lumborum block for pain relief after cesarean delivery: a randomized controlled trial. BMC Anesthesiol. 2021 Mar 25;21(1):90. doi: 10.1186/s12871-021-01309-6. |
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| 2, 6, 12 and 24 hours postoperatively |
| Incidence postoperative nausea and vomiting | The presence of nausea and/or vomiting will be recorded during the first 24 postoperative hours PONV SCORE 0: No nausea or vomiting
| First 24 hours postoperatively |
| Incidence of pruritis | The incidence of pruritis will be recorded during the first 24 postoperative hours. Pruritus will be assessed using the following scale: 0: No pruritis
| First 24 hours postoperatively |
| Obstetric Quality of Recovery -11(ObsQoR-11) Score | Quality of recovery will be assessed using the Obstetric Quality of Recovery -11(ObsQoR-11) Score questionnaire, which concists of 11 items scored from 0 to 10, with a total score ranging from 0-110, where higher scores indicate better postoperative recovery. | 24 hours postoperatively |
| Samsun |
| Turkey (Türkiye) |
| Background | Kosem, A., Ozcan, M. S., Iscan, G., Ozden, E. S., Alkaya Solmaz, F., & Kirdemir, P. (2024). Transversalis Fascia Plane Block Compared with Transversus Abdominis Plane Block for Postoperative Analgesia in Cesarean Section Under Spinal Anesthesia: A Retrospective Study. JARSS, 32(1), 11-19. |
| 30852882 | Background | Salama ER. Ultrasound-guided bilateral quadratus lumborum block vs. intrathecal morphine for postoperative analgesia after cesarean section: a randomized controlled trial. Korean J Anesthesiol. 2020 Apr;73(2):121-128. doi: 10.4097/kja.d.18.00269. Epub 2019 Mar 8. |
| 29561267 | Background | Lim G, Facco FL, Nathan N, Waters JH, Wong CA, Eltzschig HK. A Review of the Impact of Obstetric Anesthesia on Maternal and Neonatal Outcomes. Anesthesiology. 2018 Jul;129(1):192-215. doi: 10.1097/ALN.0000000000002182. |
| 28625307 | Background | Carvalho B, Butwick AJ. Postcesarean delivery analgesia. Best Pract Res Clin Anaesthesiol. 2017 Mar;31(1):69-79. doi: 10.1016/j.bpa.2017.01.003. Epub 2017 Jan 12. |
| 35223910 | Background | Jemal B, Mohammed F, Tesema HG, Ahmed S, Mohammed A, Regasa T, Obsa MS. Analgesic Efficacy of Spinal Morphine in Comparison With Transversus Abdominis Plane Block for Postoperative Pain Management in Patients Undergoing Cesarean Section Under Spinal Anesthesia: A Randomized Controlled Trial. Front Med (Lausanne). 2022 Feb 9;9:814538. doi: 10.3389/fmed.2022.814538. eCollection 2022. |