Ondansetron Lozenge Versus Intravenous for Prevention of Shivering in Tonsillectomy

Effect of Ondansetron Lozenge Versus Intravenous for Prevention of Shivering in Tonsillectomy: A Randomized Controlled Trial

This study aims to compare the effect of ondansetron lozenge and intravenous for prevention of shivering in tonsillectomy.

Tonsillectomy is one of the most common surgeries in children. The main reason for morbidity in patients undergoing surgical procedures is post-operative complications.

Shivering is random spontaneous and asynchronous skeletal muscle contractions that increases the basal metabolism and is characterized to be a defense mechanism for regulation of temperature.

Ondansetron is a selective antagonist for receptor 5-hydroxytryptamine 3 and is very effective in the prevention and treatment of shivering intra- and post-operation.

Inclusion Criteria:

• Age from 4 to 15 years.
• Both sexes.
• American Society of Anesthesiology (ASA) physical status I-II.
• Children undergoing tonsillectomy under general anesthesia.

Exclusion Criteria:

• Allergy to ondansetron.
• History of sleep apnea.
• Cardiac and respiratory diseases.
• Upper respiratory tract infection.
• Taking corticosteroids.