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Gestational diabetes mellitus (GDM) is one of the most common clinical conditions in pregnancy, with an increasing incidence due to the rise in overweight women and the postponement of motherhood. It is associated with perinatal complications and an increased risk of developing prediabetes and type 2 diabetes after delivery. Therefore, it is recommended that a 75g oral glucose tolerance test (OGTT-75g) be performed between 6 and 12 weeks postpartum. Despite its relevance, the rate of adherence to the test is low. Recent studies also indicate that measuring blood glucose one hour after the overload may be more sensitive than the traditional two-hour measurement in the early detection of dysglycemia. This study aims to evaluate strategies for qualifying the screening of metabolic changes in the postpartum period among women with GDM. The objectives are: (1) to analyze the impact of sending reminders via WhatsApp on the attendance rate for the 75g OGTT; and (2) to compare the frequency of prediabetes and diabetes diagnoses using two different diagnostic strategies applied to the same test-the traditional (fasting and 2-hour blood glucose) and the alternative (fasting and 1-hour blood glucose).
Gestational diabetes is one of the most common complications during pregnancy. With the increase in obesity and overweight in the population, as well as the postponement of motherhood, its incidence has been steadily increasing.
It is associated with complications such as polyhydramnios, macrosomia, premature labor, fetal death, hypoglycemia, and neonatal respiratory distress. Given the increase in the incidence of gestational diabetes and its clinical and epidemiological importance, a better understanding of the disease can promote improved care and prevention of its complications.
Women diagnosed with gestational diabetes mellitus (GDM) are at increased risk of developing prediabetes and type 2 diabetes in the years following childbirth. For this reason, national and international guidelines recommend performing a 75g oral glucose tolerance test (OGTT-75g) in the postpartum period, usually between six and 12 weeks after delivery, as a strategy for reclassifying glycemic status and early identification of persistent metabolic changes.
Despite the clinical relevance of the OGTT-75g in the follow-up of women with GDM, the rate of attendance for the test is notoriously low, especially in public health services. The reasons are multifactorial and include task overload in the postpartum period, logistical barriers, low risk perception, and the absence of systematic strategies to reinforce attendance. Simple interventions, such as sending reminders via electronic messages, have shown promise.
Considering the clinical and epidemiological relevance of GDM and these two complementary challenges-low attendance rates for screening and the diagnostic limitations of the current protocol-we propose two lines of investigation in this study:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | No Intervention | Control Group (current practice): will not receive reminder messages for the exam. | |
| Intervention group | Experimental | Intervention Group: will receive automatic reminder messages via WhatsApp on days D-7 and D-3 in relation to the scheduled date for the exam. If the patient does not attend, she will receive a single additional message on the following business day, offering the possibility of rescheduling. Rescheduled exams will not receive new reminders. The message sent will contain a read receipt request to ensure that the patient has received the text. If the patient requests to reschedule the exam before the originally scheduled date, we will consider the new date as D for sending reminder messages. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Whatsapp message | Other | Automatic reminder messages via WhatsApp on days D-7 and D-3 in relation to the scheduled date for the exam. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of patients that attend to the postpartum OGTT | Impact of electronic messages in the attendance rate of postpartum women with GDM at the TOTG-75g exam between 6 and 12 weeks after delivery | From enrollment to the end of the recommended timeframe for postpartum OGTT (6 to 12 weeks after delivery) |
| Measure | Description | Time Frame |
|---|---|---|
| Dysglycemia rate according to diagnostic set of criteria | Compare the prevalence of prediabetes and diabetes in the postpartum period according to two diagnostic strategies applied to the 75g OGTT: Strategy A (currently in use): fasting blood glucose measurements and measurements two hours after glucose loading Strategy B (under investigation): fasting blood glucose measurements and measurements one hour after glucose loading |
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Inclusion Criteria:
Exclusion Criteria:
Withdrawal of consent Failure to complete the TOTG exam due to vomiting (exclusion from analysis 2 only)
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Tatiana A Zaccara, MD PhD | Contact | +551126616209 | tatiana.assuncao@hc.fm.usp.br |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Sao Paulo General Hospital | Recruiting | São Paulo | São Paulo | 05.403-905 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38574892 | Background | Milluzzo A, Manuella L, Frittitta L, Sciacca L. Efficacy of a phone reminder to improve adherence to post-partum glucose tolerance testing after gestational diabetes and clinical predictors of post-partum follow-up compliance. Diabetes Res Clin Pract. 2024 Apr;210:111653. doi: 10.1016/j.diabres.2024.111653. Epub 2024 Apr 2. | |
| 40392998 |
| Label | URL |
|---|---|
| Related Info | View source |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Mar 11, 2026 | Mar 17, 2026 | Prot_SAP_000.pdf |
| ICF | No | No | Yes | Informed Consent Form | Mar 11, 2026 | Mar 17, 2026 | ICF_001.pdf |
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| ID | Term |
|---|---|
| D016640 | Diabetes, Gestational |
| D011236 | Prediabetic State |
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D044882 | Glucose Metabolism Disorders |
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This is a randomized, open-label clinical trial with two parallel groups, aiming to evaluate the effect of sending reminder messages via institutional WhatsApp on the attendance rate at TOTG-75g in the postpartum period.
Eligible participants will be randomly allocated, using a computer-generated sequence, into two groups:
Control Group (current practice): will not receive reminder messages for the exam.
Intervention Group: will receive automatic reminder messages via WhatsApp on days D-7 and D-3 in relation to the scheduled date for the exam. If the patient does not attend, she will receive a single additional message on the following business day, offering the possibility of rescheduling. Rescheduled exams will not receive new reminders. The message sent will contain a read receipt request to ensure that the patient has received the text. If the patient requests to reschedule the exam before the originally scheduled date, we will consider the new date as D
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| From enrollment to OGTT test (6 to 12 weeks after delivery) |
| Egan AM, Dunne FP. Rethinking Postpartum Glucose Assessment: Is One-Hour Testing the Key to Success? Diabetes Care. 2025 Jun 1;48(6):874-876. doi: 10.2337/dci25-0021. No abstract available. |
| 36184047 | Background | Buysschaert M, Bergman M, Valensi P. 1-h post-load plasma glucose for detecting early stages of prediabetes. Diabetes Metab. 2022 Nov;48(6):101395. doi: 10.1016/j.diabet.2022.101395. Epub 2022 Sep 29. |
| 40029070 | Background | Retnakaran R, Ye C, Kramer CK, Hanley AJ, Connelly PW, Sermer M, Zinman B. One-Hour Oral Glucose Tolerance Test for the Postpartum Reclassification of Women With Hyperglycemia in Pregnancy. Diabetes Care. 2025 Jun 1;48(6):887-895. doi: 10.2337/dc24-1848. |
| 36554709 | Background | McIntyre HD, Fuglsang J, Kampmann U, Knorr S, Ovesen P. Hyperglycemia in Pregnancy and Women's Health in the 21st Century. Int J Environ Res Public Health. 2022 Dec 15;19(24):16827. doi: 10.3390/ijerph192416827. |
| 25574889 | Background | Bozkurt L, Gobl CS, Pfligl L, Leitner K, Bancher-Todesca D, Luger A, Baumgartner-Parzer S, Pacini G, Kautzky-Willer A. Pathophysiological characteristics and effects of obesity in women with early and late manifestation of gestational diabetes diagnosed by the International Association of Diabetes and Pregnancy Study Groups criteria. J Clin Endocrinol Metab. 2015 Mar;100(3):1113-20. doi: 10.1210/jc.2014-4055. Epub 2015 Jan 9. |
| 26433807 | Background | Hod M, Kapur A, Sacks DA, Hadar E, Agarwal M, Di Renzo GC, Cabero Roura L, McIntyre HD, Morris JL, Divakar H. The International Federation of Gynecology and Obstetrics (FIGO) Initiative on gestational diabetes mellitus: A pragmatic guide for diagnosis, management, and care. Int J Gynaecol Obstet. 2015 Oct;131 Suppl 3:S173-211. doi: 10.1016/S0020-7292(15)30033-3. No abstract available. |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |