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In ageing populations, the main risk is the development of a syndrome of frailty, characterized by the addition of polymorbidity, polymedication, psychosocial difficulties, cognitive disorders, ... This functional decline is linked to a reduction in the person's functional reserves, and will lead to an increase in health problems, hospitalizations and, ultimately, mortality. People living with HIV (PLWH) over 50 develop the same kind of comorbidities as HIV-uninfected people over 75 years-old.
In Belgium, the care of PLWH< 75 years with frailty syndrome is not reimbursed by healthcare insurance, and geriatric assessment and management is therefore not possible in this age group, despite the very real need.
Goals of this project are:
Projets proposal:
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| Measure | Description | Time Frame |
|---|---|---|
| number of PLWH between 65 and 74 years with frailty | Using Fried scale and complete geriatic assesment The Fried scale is a widely recognized assessment tool designed to evaluate frailty in older adults, particularly those aged 65 and above. It helps identify individuals at increased risk of adverse health outcomes, such as falls, hospitalization, disability, and mortality. The assessment is based on five key criteria: unintentional weight loss, exhaustion, low physical activity, slowness, and weakness, with each positive criterion scoring one point. Scores of 0 indicate a robust individual, 1-2 suggest a state of pre-frailty, and ≥3 confirm frailty. | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Number of PLWH with a Fried test detecting frailty | Fried scale | Baseline |
| Number of PLWH with Fried scale detecting pre-frailty condition | Fried scale |
| Measure | Description | Time Frame |
|---|---|---|
| Validate the application of the Fried scale in a population of PLWH | compared the number of the PLWH with an Fried scale of a score >/= 2 and the number of PLWH with frailty assessed by a complete geriatrician estimation | This analyse will be done at the end of the study when all patients will have complete the evaluation at one year. |
Inclusion Criteria:
Exclusion Criteria:
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all PLWH followed at the MIA center between 65 and 74 years included
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Agnes LIBOIS, MD | Contact | +3225354130 | maladiesinfectieuses@stpierre-bru.be | |
| Charlotte Martin, MD, PHD | Contact | +3225354130 | maladiesinfectieusess@stpierre-bru.be |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Saint-Pierre, centre MIA | Recruiting | Brussels | 1000 | Belgium |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16129869 | Background | Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I, Mitnitski A. A global clinical measure of fitness and frailty in elderly people. CMAJ. 2005 Aug 30;173(5):489-95. doi: 10.1503/cmaj.050051. | |
| 11253156 | Background | Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA; Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M146-56. doi: 10.1093/gerona/56.3.m146. |
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| ID | Term |
|---|---|
| D000073496 | Frailty |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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general blood test
| Baseline |
| Results of Fried scale at one year | Fried scale performed one year after the first Fried scale in those with a abnormal Fried scale at baseline ( >/=2) | one year after the first Fried scale performed at baseline |
| 35415198 | Background | Yamada Y, Kobayashi T, Condo A, Sangarlangkarn A, Ko F, Taniguchi Y, Kojima G. Prevalence of Frailty and Prefrailty in People With Human Immunodeficiency Virus Aged 50 or Older: A Systematic Review and Meta-Analysis. Open Forum Infect Dis. 2022 Apr 10;9(5):ofac129. doi: 10.1093/ofid/ofac129. eCollection 2022 May. |
| 34799510 | Background | Jones HT, Levett T, Barber TJ. Frailty in people living with HIV: an update. Curr Opin Infect Dis. 2022 Feb 1;35(1):21-30. doi: 10.1097/QCO.0000000000000798. |
| 36250271 | Background | Allavena C, Blain H, Abulizi X, Slama L, Katlama C, Delobel P, Rio V, Cagnot C, Raho-Moussa M, Makinson A, Meyer L. Prevalence and risk factors of frailty among adults living with HIV aged 70 years or older. AIDS. 2023 Jan 1;37(1):183-189. doi: 10.1097/QAD.0000000000003403. Epub 2022 Oct 11. |
| 27756678 | Background | Wing EJ. HIV and aging. Int J Infect Dis. 2016 Dec;53:61-68. doi: 10.1016/j.ijid.2016.10.004. Epub 2016 Oct 15. |