Deep Versus Moderate Neuromuscular Blocking

The Effect of Deep Versus Moderate Neuromuscular Blocking on Patients Undergoing Open Hysterectomy

This study aimed for Determination of the impacts of deep neuromuscular blockade (DNMB) on surgical outcomes, consumption of perioperative opioid analgesia, and serum levels of inflammatory cytokines in comparison to moderate NMB (MNMB).

The primary efficacy point is the extent of change in serum levels of the estimated inflammatory cytokines in PO samples relative to the preoperative levels. The secondary endpoints include the total dose of IO fentanyl and PO morphine, PO pain scores, and surgeons' rating of the surgical conditions.

Inclusion Criteria:

• Women who will be admitted to undergo elective hysterectomy

  ,-ASA grade I or II,

• Body mass index (BMI) of <35 kg/m2

Exclusion Criteria:

hemoglobin concentration of ≤7 gm%,

• the presence of neuromuscular disorders
• uncontrolled medical diseases
• autoimmune diseases, maintenance on immunosuppressant therapy for any indication
• refusal to sign the written consent