Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose of this study is to determine the maximum ratio of the twitch amplitude (T1) to the reference twitch (Tref) amplitude (T1/Tref) that provides excellent intubating conditions.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| T1/Tref <0.1 | Experimental | Participants will be intubated once the ratio of the twitch amplitude to the reference twitch amplitude (T1/Tref) <0.1 (deeper level of block) |
|
| T1/Tref <0.3 | Experimental | Participants will be intubated once the ratio of the twitch amplitude to the reference twitch amplitude T1/Tref <0.3 (intermediate depth of block) |
|
| T1/Tref <0.5 | Experimental | Participants will be intubated once the ratio of the twitch amplitude to the reference twitch amplitude T1/Tref <0.5 (shallower level of block) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Twitch amplitude <0.1 | Device | (T1/Tref) <0.1 |
| |
| Twitch amplitude <0.3 |
| Measure | Description | Time Frame |
|---|---|---|
| Maximum T1/Tref ratio associated with excellent intubating conditions | The T1/Tref ratio that leads to the highest proportion of patients being intubated under excellent conditions: T1/Tref <0.1, T1/Tref <0.3, or T1/Tref <0.5 | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of patients with excellent intubating conditions at predefined T1/Tred threshold: <0.1 | Percentage of patients, out of total patients in the T1/Tref <0.1 arm, considered to have excellent intubation conditions (using Copenhagen Consensus Conference Intubation Score) | Baseline |
| Proportion of patients with good intubating conditions at predefined T1/Tred threshold: <0.1 |
Not provided
Inclusion Criteria:
Exclusion Criteria
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| J. Ross Renew, MD | Mayo Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mayo Clinic in Florida | Jacksonville | Florida | 32224 | United States |
Not provided
| Label | URL |
|---|---|
| Mayo Clinic Clinical Trials | View source |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Other |
(T1/Tref) <0.3 |
|
| Twitch amplitude <0.5 | Other | (T1/Tref) <0.5 |
|
Percentage of patients, out of total patients in the T1/Tref <0.1 arm considered to have good intubation conditions (using Copenhagen Consensus Conference Intubation Score) |
| Baseline |
| Proportion of patients with poor intubating conditions at predefined T1/Tred threshold: <0.1 | Percentage of patients, out of total patients in the T1/Tref <0.1 arm, considered to have poor intubation conditions (using Copenhagen Consensus Conference Intubation Score) | Baseline |
| Proportion of patients with excellent intubating conditions at predefined T1/Tred threshold: <0.3 | Percentage of patients, out of total patients in the T1/Tref <0.3 arm, considered to have excellent intubation conditions (using Copenhagen Consensus Conference Intubation Score) | Baseline |
| Proportion of patients with good intubating conditions at predefined T1/Tred threshold: <0.3 | Percentage of patients, out of total patients in the T1/Tref <0.3 arm, considered to have good intubation conditions (using Copenhagen Consensus Conference Intubation Score) | Baseline |
| Proportion of patients with poor intubating conditions at predefined T1/Tred threshold: <0.3 | Percentage of patients, out of total patients in the T1/Tref <0.3 arm, considered to have poor intubation conditions (using Copenhagen Consensus Conference Intubation Score) | Baseline |
| Proportion of patients with excellent intubating conditions at predefined T1/Tred threshold: <0.5 | Percentage of patients, out of total patients in the T1/Tref <0.5 arm, considered to have excellent intubation conditions (using Copenhagen Consensus Conference Intubation Score) | Baseline |
| Proportion of patients with good intubating conditions at predefined T1/Tred threshold: <0.5 | Percentage of patients, out of total patients in the T1/Tref <0.5 arm, considered to have good intubation conditions (using Copenhagen Consensus Conference Intubation Score) | Baseline |
| Proportion of patients with poor intubating conditions at predefined T1/Tred threshold: <0.5 | Percentage of patients, out of total patients in the T1/Tref <0.5 arm, considered to have poor intubation conditions (using Copenhagen Consensus Conference Intubation Score) | Baseline |
| Time to reach specific neuromuscular block level from rocuronium administration to achieving T1/Tref <0.1 | Time to reach specific neuromuscular block level from rocuronium administration to achieving T1/Tref <0.1 will be reported in seconds | Baseline |
| Time to reach specific neuromuscular block level from rocuronium administration to achieving T1/Tref <0.3 | Time to reach specific neuromuscular block level from rocuronium administration to achieving T1/Tref <0.3 will be reported in seconds | Baseline |
| Time to reach specific neuromuscular block level from rocuronium administration to achieving T1/Tref <0.5 | Time to reach specific neuromuscular block level from rocuronium administration to achieving T1/Tref <0.5 will be reported in seconds | Baseline |