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This study aimed to detect the impact of inhaled Tranexamic acid® in pulmonary hemorrhage in pediatric intensive care unit.
Pulmonary hemorrhage, often manifested as hemoptysis, can be a severe and life-threatening condition.
Tranexamic acid (TXA)® is a lysine analog that prevents the conversion of plasminogen to plasmin and inhibits plasmin's binding to fibrin, stabilizing the fibrin matrix and reducing bleeding.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group I | Experimental | Patients received inhaled or endotracheally instilled Tranexamic acid (TXA) in addition to conventional therapy. |
|
| Group II | Experimental | Patients received conventional systemic Tranexamic acid (TXA) alone. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tranexamic acid + conventional therapy. | Drug | Patients received inhaled or endotracheally instilled Tranexamic acid (TXA) in addition to conventional therapy. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cessation of pulmonary hemorrhage | The cessation of pulmonary hemorrhage within 48 hours of starting inhaled tranexamic acid was recorded. | 48 hours of starting inhaled tranexamic acid |
| Incidence of adverse effects | Incidence of adverse effects was recorded. | 48 hours of starting inhaled tranexamic acid |
| Measure | Description | Time Frame |
|---|---|---|
| In-hospital mortality | Incidence of in-hospital mortality was recorded. | 48 hours of starting inhaled tranexamic acid |
| Length of hospital stay | Length of hospital stay was recorded from the admission till the discharge from the hospital. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tanta University | Tanta | El-Gharbia | 31527 | Egypt |
The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
After the end of study for one year.
The data will be available upon a reasonable request from the corresponding author.
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| ID | Term |
|---|---|
| D014148 | Tranexamic Acid |
| ID | Term |
|---|---|
| D003509 | Cyclohexanecarboxylic Acids |
| D000146 | Acids, Carbocyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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| Tranexamic acid | Drug | Patients received conventional systemic Tranexamic acid (TXA) alone. |
|
| Till the discharge from the hospital (Up to 2 weeks) |