Berberine Supplementation, Sprint Interval Training, and Immune Function Study

Effects of 2-Weeks of Berberine and Sprint Interval Training on Wellbeing, Anaerobic Power, and Monocyte Number and Function

The purpose of this clinical trial is to investigate the effects of a 2-week intervention involving berberine supplementation or sprint training in isolation as well as berberine combined with sprint training on well-being, anaerobic power, and monocyte number and function in individuals experiencing mild mental health challenges. The main questions it aims to answer are:

• Does short-term berberine use or sprint training improve measures of mental health, psychological wellbeing, fatigue, and sleep quality?
• Does short-term berberine use or sprint training improve measures of anaerobic power generation?
• Does short-term berberine use or sprint training improve circulating biomarkers of inflammation?
• Does short-term berberine use or sprint training improve monocyte number, function, and cytokine production?

Inclusion Criteria:

• Males and Females
• Aged 18-45
• DASS-21 subscale scores indicating "Mild" or greater category for Depression ≥ 10, Anxiety ≥ 7, and Stress ≥ 11

Exclusion Criteria:

• Regular berberine intake in the last 2 months
• Performs SIT regularly in the last month
• Pregnant or planning to become pregnant
• Chronic use of anti-inflammatory medication or medications that affect liver metabolism
• Prior history of chronic conditions such as Cardiovascular Disease, Diabetes, and Cancer
• Severe and untreated anxiety or depression
• Severe Peanut Allergies
• Any contraindications to performing high intensity exercise