The Preventive Risk Outreach And Cascade Testing

The Preventive Risk Outreach and Cascade Testing (PROACT)

The goal of this clinical trial is to learn whether a new online program developed by the research team is able to help families learn about family cancer risk and how to reduce this risk, as well as help interested family members get low-cost, at-home genetic testing for cancer risk.

The overarching goal of this study is to facilitate cascade genetic testing to reduce the burden of cancer in families with hereditary cancer syndromes (HCS). We will evaluate different versions of a point-of-care cascade genetic testing referral service for probands with recently detected pathogenic or likely pathogenic genetic variants.

Inclusion Criteria - Probands

1. Age ≥ 18 years old.
2. Known to carry a pathogenic or likely pathogenic variant in a gene included in the 2024 current Color Health Cancer Panel Test.
3. Have at least one (1) first- or second-degree relative who is living in the United States and has not yet had germline genetic testing.

Exclusion Criteria - Probands

1. Unable to read and write English or Spanish.

Inclusion Criteria - Relatives

1. Age ≥ 18 years old.
2. Resides in the United States.

Exclusion Criteria - Relatives

1. Completed genetic testing by a clinician within the last 5 years that included the pathogenic or likely pathogenic variant.
2. Not a first- or second-degree relative of the proband.