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Test whether a doctor-formulated protein made from real beef is more digestible than standard whey protein powder. For the first 30 days, participants receive either standard whey protein powder or Equip Protein and track how the gut responds weekly. At the 30 day mark, all participants receive the standard Equip protein to track differences in digestability.
This remotely administered decentralized trial is designed to critically assess the digestive and overall well-being impact of Equip's Prime Protein, a beef-based protein powder, in comparison to standard whey protein. In an era where nutrition claims are often promoted without rigorous testing, Equip is committed to substantiating the benefits of its protein powder through real-world evidence. Over a span of 60 days, this study will employ a cross-over design whereby participants will document their digestive experiences, energy levels, and overall health, providing valuable insights into how each protein source influences gut comfort and tolerability.
Participants in this study will either start with the standard whey protein and transition to Equip's chocolate-flavored beef protein at the halfway mark or use Equip's product from the outset. This methodology allows for a comprehensive comparison between the two protein sources, aiming to offer individuals a clearer understanding of how different proteins affect their gut health. Through daily structured surveys and feedback, participants will not only learn how their bodies respond to each protein type but also contribute to critical data that could potentially elevate the standard of evidence within the supplement industry.
The significance of this study extends beyond individual health, aiming to challenge and reshape the broader nutrition and supplement landscape. Most companies in the supplement industry base their claims on marketing rather than empirical evidence. By conducting this rigorous, real-world study, Equip is holding itself to a standard of scientific accountability and transparency. The findings from this trial will not only inform participants' choices but also aim to advance the entire field towards cleaner, evidence-based nutrition practices. By identifying which protein source better supports digestion and overall comfort, this study stands to make a meaningful impact on public health and industry standards, moving the focus from marketing claims to measurable, scientifically valid outcomes.
More information can be found on the study recruitment page here: https://app.efforia.com/prime-protein-chocolate-gastrointestinal-health/
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Crossover longitudinal where participants act as their own control - whey arm | Sham Comparator | 30 % of participants receive a standard chocolate whey protein, followed by the Equip chocolate beef protein. |
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| Crossover longitudinal where participants act as their own control - beef arm | Experimental | 70 % of participants receive Equip chocolate protein followed by another Equip chocolate protein. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Beef protein | Dietary Supplement | Original beef protein powder chocolate flavor, manufactured by Equip, packed with 21g of complete protein, plus naturally occurring collagen and gelatin |
| Measure | Description | Time Frame |
|---|---|---|
| PROMIS® Scale v1.0 - Gastrointestinal Constipation 9a | Outcome Measure Description: Change from baseline in gastrointestinal constipation as assessed by the Patient-Reported Outcomes Measurement Information System® (PROMIS®) Gastrointestinal Constipation 9a Scale, Version 1.0, which evaluates constipation frequency, severity, and impact over the past 7 days. Scoring: Each item is scored 1-5; total raw scores are converted to a T-score metric (range ~25-85). Higher scores indicate more severe constipation (worse outcome). | Change from baseline (Day 1-5) in gastrointestinal constipation at 4 weeks after the start of the intervention (Day 25-35) |
| PROMIS® Scale v1.0 - Gastrointestinal Belly Pain 5a Survey | Outcome Measure Description: Change from baseline in gastrointestinal belly pain as assessed by the Patient-Reported Outcomes Measurement Information System® (PROMIS® Gastrointestinal Belly Pain 5a Scale, Version 1.0), measuring frequency and intensity of abdominal pain over the past 7 days. Scoring: Each item scored 1-5; T-score conversion range ~25-80. Higher scores indicate more severe belly pain (worse outcome). | Change from baseline (Day 1-5) in gastrointestinal belly pain at 4 weeks after the start of the intervention (Day 25-35) |
| PROMIS® Scale v1.0 - Gastrointestinal Bowel Incontinence 4a Survey | Outcome Measure Description: Change from baseline in gastrointestinal bowel incontinence as assessed by the Patient-Reported Outcomes Measurement Information System® (PROMIS® Gastrointestinal Bowel Incontinence 4a Scale, Version 1.0), evaluating frequency and impact of bowel incontinence over the past 7 days. Scoring: Each item scored 1-5; T-score conversion range ~25-80. Higher scores indicate more severe bowel incontinence (worse outcome). | Change from baseline (Day 1-5) in gastrointestinal bowel incontinence at 8 weeks after the start of the intervention (Day 55-65) |
| PROMIS Scale v1.1 - Gastrointestinal Gas and Bloating 13a | Outcome Measure Description: Change from baseline in gastrointestinal gas and bloating as assessed by the Patient-Reported Outcomes Measurement Information System® (PROMIS® Gastrointestinal Gas and Bloating 13a Scale, Version 1.1), which evaluates frequency and intensity over the past 7 days. Scoring: Each item scored 1-5; T-score conversion range ~25-85. Higher scores indicate more severe gas and bloating (worse outcome). |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Efforia | New York | New York | 10003 | United States |
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| Label | URL |
|---|---|
| Additional information and join instructions on Efforia | View source |
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Crossover observational where participants act as their own control
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Protein powders have individually been packaged into indeterminate packages so that participants are unaware of which product they are testing. They are informed prior to study start that they may be given whey or beef protein.
| Chocolate whey protein | Dietary Supplement | Whey protein isolate is a dairy-derived protein powder containing ≥90% protein by weight, with minimal lactose and fat. The product is provided as a flavored powder and administered orally when mixed with water. The product does not contain added bioactive ingredients beyond standard whey protein isolate. |
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| Change from baseline (Day 1-5) in gastrointestinal gas and bloating at 4 weeks after the start of the intervention (Day 25-35) |