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The goal of this prospective randomized control trial is to provide continued pain relief, classically long-lasting 3 to12 months, and enhanced function in patients following: both gender; male and female, age group; >50yr, healthy volunteers along with Radiographic diagnosis of knee OA with KL grade 3 and 4 in addition of Chronic knee pain ≥ 6 months and patients with ≥50% decrease in pain strength after diagnostic genicular nerve block. The main question it aims to answer is:
Is ultrasound-guided genicular nerve RFA more efficient in lowering pain intensity at six months contrasted with fluoroscopic guided method in patients with chronic knee osteoarthritis? Researchers will compare Group A (Fluoroscopic) to Group B (Ultrasound) to see comparison in efficiency of ultrasound guided against fluoroscopic guided genicular nerves block for decrease in pain intensity and functional improvement.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group B | Experimental | Intervention group in which genicular nerves radiofrequency ablation will be done with the help ultrasound guidance. |
|
| Group A | Active Comparator | Control group in which genicular nerves radiofrequency ablation will be done with the help of fluoroscopic guidance. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ultrasound Guided | Procedure | Genicular nerves radiofrequency ablation will be done with the help of ultrasound guidance. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Effectiveness of Block | Block will be considered effective if decrease in pain score from baseline is >50% at six months. And this will measure by using the 11-point Numeric Rating Scale (NRS) where 0 = no pain and 10 = worst imaginable pain. | Post procedure 2 weeks, then follow up after 2, 4 and 6 months. |
| Measure | Description | Time Frame |
|---|---|---|
| Functional Improvement after block | Functional improvement after genicular nerve block is describe as > 20 % decrease in KOOS PS score from baseline at six months. Functional condition will be assessed using the Knee injury and osteoarthritis outcomes score-Physical function short form (KOOS-PS) tool. Minimum score is 0 and maximum is 20 which will then be converted into ratio from 0 to 100%, 0 means no functional impairment and 100 means maximum functional impairment. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ali Sarfraz Siddiqui, MBBS-FCPS | Contact | +92 021-38104397 | 4397 | sarfraz.siddiqui@aku.edu |
| Name | Affiliation | Role |
|---|---|---|
| Ali Sarfraz Siddiqui, MBBS-FCPS | Aga Khan University | Principal Investigator |
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| Fluoroscope Guided | Procedure | Control group in which genicular nerves radiofrequency ablation will be done with the help of fluoroscopic guidance. |
|
| 6 months |