Islet transplantation is associated with drastically improvement glucose control in people with type 1 diabetes. This treatment resulted in the disappearance of severe hypoglycemic events. However, its long-term effectiveness is limited by progressive loss of graft function. Currently, there is no standardized method to detect early dysfunction of the transplanted islets.

This study aims to determine whether a parameter derived from continuous glucose monitoring (CGM), Time in Tight Range (70-140 mg/dL), is associated with pancreatic islet grafts function.

The study hypothesis is that a decrease in Time in Tight Range reflects early loss of islet graft function.

Inclusion Criteria:

• ≥18 years old

• Insulin-dependent diabetes (type 1 diabetes, secondary to chronic pancreatitis, MODY, cystic fibrosis)

• Patient who has completed a full cycle of pancreatic islet transplantation, either:

  • Islet Transplantation Alone (ITA), or
  • Islet After Kidney (IAK), or
  • Simultaneous Islet Kidney (SIK), with >10,000 IEQ/kg of recipient body weight, or <10,000 IEQ/kg but having achieved insulin independence

• Patient who has provided consent for reuse of their data for this research

Exclusion Criteria:

• Patient refusal to wear continuous glucose monitoring device
• Pancreatic islet autotransplantation
• Inability to provide informed consent (e.g., difficulties understanding study information)
• Patient under judicial protection (safeguard of justice)
• Patient under guardianship or curatorship

Insulin-dependent diabetes (type 1 diabetes, secondary to chronic pancreatitis, MODY, cystic fibrosis).