Supply chain disruptions have led to shortages in test swabs which are used to collect respiratory samples. Lack of these test swabs can reduce a hospital or state's ability to test patients for COVID-19.

To address this shortage, many manufacturers, hospitals and individuals have designed non-traditional 3D printed swabs for COVID-19 diagnosis that could potentially meet demands for nasal swabs. However, questions regarding the safety and effectiveness of these swabs remain.

This study will provide additional, statistically supported evidence as to the safety and efficacy of novel swabs.

This is a prospective, multi-site, non-inferiority study providing a comparison between the performance of traditional, standard of care (SoC) and alternative (ALT) nasal swabs. Nasal swabs and swabbing site of interest for this study is the nasopharynx (NP swab). The primary outcomes of this study are the rate of adverse events and the agreement in laboratory viral detection between SoC and ALT swabs.

Inclusion Criteria:

• Symptomatic or COVID-19 positive (within the past 2 weeks)
• Has a COVID-19 positive household member
• Female and male Veterans or female and male VHA employees
• Able and willing to give informed consent

Exclusion Criteria:

• Self-reported history of frequent nosebleeds or a diagnosis of coagulopathy or any bleeding disorders
• Unsuitability for mid-turbinate or nasopharyngeal swabbing due to prior surgery
• Need for legally authorized representative for purpose of giving consent

Employees and patients with recent (<2 weeks) COVID-19 diagnosis for themselves or a member of their home, or who are symptomatic with one or more COVID-19 symptoms are eligible.