Adding 1% Metformin Gel to Bone Graft in Association With Immediate Dental Implants

The Impact of Adding 1% Metformin Gel to Bone Graft in Association With Immediate Dental Implants

This study aimed to investigate whether combining xenografts with Metformin Gel gel enhances bone regeneration and improves implant outcomes.

The placement of a dental implant in an extraction socket at the time of extraction or explanation is known as immediate implant placement whereas delayed placement of implant signifies the implant placement in edentulous areas where healing has completed with new bone formation after the loss of tooth/teeth.

The xenograft is derived from other organisms, mainly bovine. It provides long-term volume stability. Porous natural hydroxyapatite can be obtained from animal bones.

Metformin HCl (1, 1-dimethylbiguanide HCl) (MF), is one of the most commonly used oral anti-hyperglycemic agents for the treatment of type 2 diabetes mellitus. The use of MF may reduce the association between diabetes and fractures in patients with both type 1 and type 2DM.MF increase type I collagen production in osteoblast-like cell lines and stimulated alkaline phosphate activity in osteoblasts.

Inclusion Criteria:

• Age from 18 to 40 years.
• Both sexes.
• Adult individual with non-restorable tooth in esthetic and premolars area and seeking for immediate implant placement.
• Systemically healthy patients were selected for implant surgery according to the criteria of Cornell medical index and its modifications.
• The recipient site of the implant should be free from any pathological conditions.
• Sufficient vertical bone height to safely place at least 12 mm long dental implant.

Exclusion Criteria:

• Smokers.
• Pregnant or lactating female patients.
• Patients with parafunctional habits such as bruxism and clenching.
• Presence of acute infection around the failing tooth.
• Perforation and/or loss of the labial bony plate following tooth removal and/or implant osteotomy.
• Inability to attain primary implant stability following immediate implant placement.