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This study aimed to investigate whether combining xenografts with Metformin Gel gel enhances bone regeneration and improves implant outcomes.
The placement of a dental implant in an extraction socket at the time of extraction or explanation is known as immediate implant placement whereas delayed placement of implant signifies the implant placement in edentulous areas where healing has completed with new bone formation after the loss of tooth/teeth.
The xenograft is derived from other organisms, mainly bovine. It provides long-term volume stability. Porous natural hydroxyapatite can be obtained from animal bones.
Metformin HCl (1, 1-dimethylbiguanide HCl) (MF), is one of the most commonly used oral anti-hyperglycemic agents for the treatment of type 2 diabetes mellitus. The use of MF may reduce the association between diabetes and fractures in patients with both type 1 and type 2DM.MF increase type I collagen production in osteoblast-like cell lines and stimulated alkaline phosphate activity in osteoblasts.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group I | Experimental | Patients received immediate implant combined with a mixture of 1%metformin gel and xenograft. |
|
| Group II | Experimental | Patients received immediate implant combined with xenograft alone. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Metformin gel-xenograft | Other | Patients received immediate implant combined with a mixture of 1%metformin gel and xenograft. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Assessment of Implant primary stability | Implant primary stability was assessed using Resonance Frequency Analysis at baseline and at 3, 6, and 12 months after implant placement. | 12 months after implant placement |
| Measure | Description | Time Frame |
|---|---|---|
| Soft tissue change of modified Plaque Iindex | Soft tissue change of modified Plaque Iindex (mPI) was done at baseline and 3, 6 and 12 months after implant placement | 12 months after implant placement |
| Soft tissue change of modified sulcus bleeding index |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Al-Azhar University (Assiut) | Asyut | 71524 | Egypt |
The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
After the end of study for one year.
The data will be available upon a reasonable request from the corresponding author.
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| ID | Term |
|---|---|
| D014183 | Transplantation, Heterologous |
| ID | Term |
|---|---|
| D014180 | Transplantation |
| D013514 | Surgical Procedures, Operative |
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| Xenograft | Other | Patients received immediate implant combined with xenograft alone. |
|
Soft tissue change of modified sulcus bleeding index was done at baseline and 3, 6 and 12 months after implant placement |
| 12 months after implant placement |
| Soft tissue change of peri-implant probing depth | Soft tissue change of peri-implant probing depth (PPD) was done at baseline and 3, 6 and 12 months after implant placement | 12 months after implant placement |
| Radiographic Evaluation to horizontal jumping gap | Radiographic Evaluation to horizontal jumping gap using CBCT was done at baseline and 6 and 12 months after implant insertion | 12 months after implant insertion |
| Radiographic Evaluation to buccal bone thickness | Radiographic Evaluation to buccal bone thickness using CBCT and vertical marginal bone level and bone density were done at baseline and 6 and 12 months after implant insertion | 12 months after implant insertion |
| Biochemical assessment of peri-implant crevecular fluid level | Biochemical assessment of peri-implant crevecular fluid level of osteopontin by ELISA was done at basline,1week; and 3 months after implant placement. | 3 months after implant placement |