This study evaluates the bioequivalence and adhesion performance of a test rivastigmine transdermal patch compared with the reference product, Exelon® Patch 10 (9.5 mg/24 h), in healthy adult volunteers of both sexes under fasting conditions. The pharmacokinetic profiles will be compared to assess whether the test product demonstrates equivalent rate and extent of absorption to the reference formulation. Patch adhesion will also be evaluated throughout the dosing interval to determine whether the test product shows high adhesion (>90%) or non-inferior adhesion compared with the reference product.

Inclusion Criteria:

• Body mass index (BMI) between 18.5 and 30.0 kg/m².
• Non-smokers or former smokers who stopped smoking at least 1 year prior to screening.
• Clinically healthy based on medical history, physical examination, vital signs, ECG, and clinical laboratory tests.
• Negative screening for HIV, hepatitis B, and hepatitis C.
• Female participants must not be pregnant or breastfeeding and must have a negative pregnancy test.
• No hair, wounds, or dermatological conditions at the intended patch application site (upper arm).
• Able to understand the study procedures and provide written informed consent

Exclusion Criteria:

• History or presence of clinically significant cardiovascular, hepatic, renal, gastrointestinal, neurological, psychiatric, metabolic, pulmonary, or dermatological diseases.
• Known hypersensitivity to rivastigmine, carbamate derivatives, or any component of the study formulation.
• Abnormal clinical laboratory results, vital signs, or ECG considered clinically significant by the investigator.
• Positive test results for drugs of abuse, alcohol misuse, HIV, hepatitis B, or hepatitis C.
• Use of prescription or non-prescription medications that could interfere with the study drug within a defined period prior to dosing, as determined by the investigator.
• Participation in another clinical trial or exposure to an investigational drug within the previous 6 months.
• Blood donation or significant blood loss within 3 months prior to the study.
• Consumption of grapefruit-containing products, alcohol, or substances that could interfere with drug metabolism prior to dosing.
• Use of medications known to significantly affect hepatic metabolism.
• Dermatological conditions or skin alterations that could interfere with patch adhesion or drug absorption.
• Positive or suspected infection with SARS-CoV-2 prior to study periods.
• Any condition that, in the investigator's judgment, could interfere with study participation or the interpretation of study results.

Individual participant data (IPD) will not be shared due to confidentiality restrictions and institutional policies regarding participant-level clinical data.