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This is a study exploring measurable markers in the blood of patients with testicular tumors. The investigators will focus on the importance of measuring and analyzing these markers for their prognostic value and predictive response to treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patient with a testicular cell germ tumor | Other | All patients will have the same samples, at the time of orchidectomy, then during chemotherapy and during follow-up. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| blood sampling | Biological | Blood samples will allow the measurement of AFP, LDH and HCG as well as the measurement of testosterone, glucose, cholesterol, triglycerides and bile acids |
| Measure | Description | Time Frame |
|---|---|---|
| To compare bile acid levels in healthy testicular tissues and in tumorous testicular tissues in patients with testicular germ cell tumor | The investigators hypothesis is that bile acid levels are higher in tumor tissues compared to those present in healthy tissues of patients with testicular germ cell tumors, making them a marker of these tumors. Furthermore, the investigators suggest that blood bile acid levels and their composition are a relevant prognostic marker of these tumors. | During orchidectomy |
| Measure | Description | Time Frame |
|---|---|---|
| Composition of bile acids in healthy and tumor testicular tissues | Perioperative | |
| Correlation between blood bile acid levels and survival | From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 100 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lise LACLAUTRE | Contact | 0473754963 | promo_interne_drci@chu-clermontferrand.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Clermont-Ferrand | Recruiting | Clermont-Ferrand | France |
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Prospective single-center study, RIPH type 2 protocol
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Masking Description
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| Tissue sampling | Procedure | On these tissues (tumoral and non-tumoral), the investigators will carry out analysis of the bile acid composition by mass spectrometry, molecular characterization by RNAseq, histological characterization and analysis in cell culture |
|
| Correlation between blood bile acid levels and the prognostic stage | From enrollment to 24 months after the end of treatment |
| Correlation between bile acid levels and tumor markers | From enrollment to 24 months after the end of treatment |
| Correlation bile acid levels kinetics with the response to chemotherapy | From enrollment to 24 months after the end of treatment |
| Correlation between bile acid level kinetics and survival | From enrollment to 24 months after the end of treatment |
| Analysis of chemosensitivity of tumor cells in vitro | From the end of chemotherapy to 24 months after the end of treatment |
| ID | Term |
|---|---|
| D013736 | Testicular Neoplasms |
| ID | Term |
|---|---|
| D004701 | Endocrine Gland Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D005834 | Genital Neoplasms, Male |
| D014565 | Urogenital Neoplasms |
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D004700 | Endocrine System Diseases |
| D013733 | Testicular Diseases |
| D006058 | Gonadal Disorders |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
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