The Mediterranean Diet Based on Local Foods for Obese Patients

The Mediterranean Diet Based on Local Foods for Obese Patients: A Study of Anthropometric Parameters, Inflammatory Markers, and Gut Microbiota

The goal of this clinical trial is to examine the efficacy of a Mediterranean diet based on local Indonesian foods on alterations in gut microbiota, body composition, and metabolic biomarkers in obese subjects. The main questions it aims to answer are:

Dose Mediterranean diet modification based on local food ingredients can result in greater weight loss, greater reductions in inflammatory markers, improve gut microbiota diversity compared to a balanced low-calorie diet in obese patients?

Researchers will compare Mediterranean diet modification based on local food to low calorie diet.

Participant will:

• Participants received a low-calorie diet of approximately 1.500 kcal/day according to their randomized group assignments, consisting of breakfast, lunch, dinner, and snacks. Both groups will receive dietary education and physical activity guidance tailored to their weight loss needs.
• Participants were instructed to complete a food intake record and report their consumption to the researchers using intake forms and photographs of the food packaging. Weekly meetings were held via Zoom to evaluate dietary compliance.
• Blood samples and fecal specimens were collected at baseline (week 0) and at week 4 of the study.

Inclusion Criteria:

• Women who were obese, as defined by a BMI of at least 27.
• Aged 18-50 years
• Subjects with a non-shift work schedule
• Willing to follow the research procedures and sign the informed consent form.

Exclusion Criteria:

• Subjects with a history of type 2 diabetes, kidney disease, liver disease, or thyroid disorders, as indicated by medical history or medical records.
• Contraindications for the MF-BIA examination include the use of pacemakers or implants and a history of amputation.
• Pregnant or within 40 days of childbirth
• Adults with edema
• Taking medications with hyperglycemic effects, such as beta-blockers, thiazides, corticosteroids, calcineurin inhibitors, anti-dyslipidemic medications (e.g., statins, fibrates, niacin, and bile acid sequestrants), or antibiotics.
• History of food allergies