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| ID | Type | Description | Link |
|---|---|---|---|
| 1RM1DA063351 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Drug Abuse (NIDA) | NIH |
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This observational research study is studying how substance use impacts scarring and inflammation of the heart. This study involves one study visit for a cardiac MRI.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Current Stimulant Use | Used stimulants (amphetamines, cocaine, etc.) in past year | ||
| Past Stimulant Use | Previously used stimulants (amphetamines, cocaine, etc.) but not in the last 12 months | ||
| No Stimulant use | Never used stimulants (amphetamines, cocaine, etc.) |
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| Measure | Description | Time Frame |
|---|---|---|
| Cardiac MRI | CMR assessments to provide detailed myocardial characterization (e.g. diffuse inflammation (nT1), myocardial fibrosis (ECV), and myocardial scar assessed using LGE) | Visit 1, up to 2 hours |
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Inclusion Criteria:
- Participants with and without HIV enrolled in the MACS/WIHS Combined Cohort Study (MWCCS) Atlanta, Baltimore, Bronx, and San Francisco study sites
Exclusion Criteria:
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Participants with and without HIV enrolled in the MACS/WIHS Combined Cohort Study (MWCCS) Atlanta, Baltimore, Bronx, and San Francisco study sites
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Heather Freasier, MS, RD | Contact | 415-683-9895 | heather.freasier@ucsf.edu | |
| Nneka Emenyonu, PhD | Contact | Nneka.Emenyonu@ucsf.edu |
| Name | Affiliation | Role |
|---|---|---|
| Phyllis Tien, MD | University of California, San Francisco | Principal Investigator |
| Elise Riley, PhD | University of California, San Francisco | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of California, San Francisco | San Francisco | California | 94115 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32919207 | Background | Riley ED, Vittinghoff E, Wu AHB, Coffin PO, Hsue PY, Kazi DS, Wade A, Braun C, Lynch KL. Impact of polysubstance use on high-sensitivity cardiac troponin I over time in homeless and unstably housed women. Drug Alcohol Depend. 2020 Dec 1;217:108252. doi: 10.1016/j.drugalcdep.2020.108252. Epub 2020 Aug 30. | |
| 35872529 | Background | Riley ED, Kizer JR, Tien PC, Vittinghoff E, Lynch KL, Wu AHB, Coffin PO, Beck-Engeser G, Braun C, Hunt PW. Multiple substance use, inflammation and cardiac stretch in women living with HIV. Drug Alcohol Depend. 2022 Sep 1;238:109564. doi: 10.1016/j.drugalcdep.2022.109564. Epub 2022 Jul 8. |
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data for MWCCS research participants are available from the JHU Institutional data repository managed by the MWCCS Data Analysis and Sharing Center (DASC) by submission of a Concept Sheet at https://statepi.jhsph.edu/mwccs/work-with-us/
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| ID | Term |
|---|---|
| D000163 | Acquired Immunodeficiency Syndrome |
| ID | Term |
|---|---|
| D015658 | HIV Infections |
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
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| Emory University, School of Medicine | Atlanta | Georgia | 30322 | United States |
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| Johns Hopkins University | Baltimore | Maryland | 21218 | United States |
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| Albert Einstein College of Medicine | The Bronx | New York | 10462 | United States |
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| D015229 |
| Sexually Transmitted Diseases, Viral |
| D012749 | Sexually Transmitted Diseases |
| D016180 | Lentivirus Infections |
| D012192 | Retroviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D012897 | Slow Virus Diseases |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D007153 | Immunologic Deficiency Syndromes |
| D007154 | Immune System Diseases |