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| Name | Class |
|---|---|
| National Heart Foundation of Bangladesh | OTHER |
| Vital Strategies | OTHER |
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The goal of this pre-post study is to assess the risk of hyperkalemia in adults with hypertension on medication in Bangladesh. The main questions it aims to answer are:
Is the risk of hyperkalemia after the initiation of Low Sodium Salt Substitute (LSSS) in people on antihypertensive medication (especially RASi) large enough to be concerned about its broad use in this population?
Does initiation of LSSS correct hypokalemia in people on antihypertensive medication (especially RASi) with low serum potassium levels?
Participants will be asked to reduce overall salt intake and to use LSSS on every occasion where regular salt would normally be used, including as cooking salt.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Low sodium salt substitute (LSSS) | Experimental | Participants are asked to reduce overall salt intake and to use LSSS on every occasion where regular salt would normally be used, including as cooking salt |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Low-sodium salt substitute | Dietary Supplement | The low sodium salt substitute contains 25% potassium chloride (KCl range; 20%-35%) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incident hyperkalemia (K ≥5.5 mmol/L) | 4 and 8 weeks | |
| Proportion of the correction of hypokalemia (from K <3.5 mmol/L to 3.5-5.0 mmol/L) | 4 and 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change in serum potassium levels | 4 and 8 weeks | |
| Change in systolic and diastolic blood pressure (mmHg) | 4 and 8 weeks | |
| Number of Participants Adherent to LSSS use |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Junichi Ishigami, MD, PhD | Contact | 14432877262 | jishiga1@jhu.edu | |
| Sohel Reza Choudhury, MD, PhD | Contact |
| Name | Affiliation | Role |
|---|---|---|
| Junichi Ishigami, MD, PhD | Johns Hopkins University | Principal Investigator |
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Individual participant data will not be shared due to institutional review board restrictions and participant privacy considerations.
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| ID | Term |
|---|---|
| D006973 | Hypertension |
| D002318 | Cardiovascular Diseases |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
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Pre-post study
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| 4 and 8 weeks |