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This interventional study assigns participants undergoing autologous hematopoietic stem cell transplantation to a supervised exercise program or usual care. The exercise program includes strength, endurance, and flexibility sessions for 8 weeks, 5 days per week. The control group receives usual care without a structured exercise program.
This interventional study is conducted at Erciyes University Faculty of Medicine, Department of Hematology in patients scheduled for autologous hematopoietic stem cell transplantation. Eligible participants are assigned to either a supervised exercise program or usual care.
The exercise intervention consists of strength, endurance, and flexibility sessions performed five days per week for eight weeks under supervision. Participants in the control group receive standard medical care without a structured exercise program.
The study aims to examine the effects of the exercise program during the transplantation process in patients undergoing autologous stem cell transplantation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise Intervention In Autologous Stem Cell Transplant Patients:A Randomized Controlled Trial | Experimental | The Exercise Group consisted of patients scheduled to undergo autologous bone marrow transplantation who were randomly assigned to the intervention arm of the study. Initial number of participants: 12 Included in final analysis: 8 Intervention:
In addition to standard medical treatment, this group received a structured therapeutic exercise program. |
|
| Exercise Intervention-Free Randomized Controlled Study in Autogenous Stem Cell Transplant Patients | No Intervention | The Control Group consisted of patients randomly assigned to the control arm of the study. Initial number of participants: 12 Included in final analysis: 7 Intervention:
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise Program | Behavioral | 8-week structured strength, endurance and flexibility exercise program performed 5 days per week. Resistance intensity was determined using 1RM, aerobic intensity using Karvonen method (40-60%), monitored with Borg Scale |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Handgrip Strength During the Transplantation Process | Change in handgrip strength measured using a hand dynamometer at four time points: 4 weeks before transplantation, 2 days before transplantation, during the engraftment period, and 2 weeks after engraftment in patients undergoing autologous bone marrow transplantation. | Baseline (4 weeks before transplantation),pre-transplant (2 days before), during engraftment, and 2 weeks post-engraftment 8(approximately 10-12 weeks total follow-up) |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Back Strength | Back strength measured using a back dynamometer (kg) at four time points during the transplantation process. | Baseline (4 weeks before transplantation), pre-transplant (2 days before), during engraftment, and 2 weeks post-engraftment (approximately 10-12 weeks total follow-up). |
| Change in Leg Strength |
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Inclusion Criteria:
Exclusion Criteria:- Unable to communicate or read in Turkish,
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| Name | Affiliation | Role |
|---|---|---|
| Mustafa KarakuÅŸ, PhD | TC Erciyes University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Erciyes University Faculty of Sport Science | Kayseri | Kayseri | 38039 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19234513 | Background | Jarden M, Baadsgaard MT, Hovgaard DJ, Boesen E, Adamsen L. A randomized trial on the effect of a multimodal intervention on physical capacity, functional performance and quality of life in adult patients undergoing allogeneic SCT. Bone Marrow Transplant. 2009 May;43(9):725-37. doi: 10.1038/bmt.2009.27. Epub 2009 Feb 23. | |
| 18026154 |
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Individual participant data (IPD) will not be shared due to institutional data protection policies and ethical restrictions
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| ID | Term |
|---|---|
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D055070 | Resistance Training |
| ID | Term |
|---|---|
| D005081 | Exercise Therapy |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
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analyses were completed with 8 patients in the exercise group and 7 patients in the control group.
The exercise group participated in an 8-week exercise program consisting of endurance, strength, and flexibility exercises performed five days per week. The 1-repetition maximum (1RM) principle was used to determine resistance training intensity, while the Karvonen method (40-60%) was used to prescribe aerobic exercise intensity. Exercise intensity was monitored using the 24-point Borg Scale. The control group did not participate in any structured exercise program.
Assessments were conducted at four time points:
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Outcome assessors and data analysts were blinded to group allocation. Due to the nature of the exercise intervention, participants and exercise supervisors were not blinded.
Leg strength measured using a leg dynamometer (kg) at four time points during the transplantation process. |
| Baseline (4 weeks before transplantation), pre-transplant (2 days before), during engraftment, and 2 weeks post-engraftment (approximately 10-12 weeks total follow-up). |
| Change in Waist Flexibility | Waist flexibility assessed by sit-and-reach test (cm) at four time points during the transplantation process. | Baseline (4 weeks before transplantation), pre-transplant (2 days before), during engraftment, and 2 weeks post-engraftment (approximately 10-12 weeks total follow-up). |
| Change in White Blood Cell Count | White blood cell count (10^9/L) obtained from routine complete blood count at four time points. | Baseline (4 weeks before transplantation), pre-transplant (2 days before), during engraftment, and 2 weeks post-engraftment (approximately 10-12 weeks total follow-up). |
| Change in Neutrophil Count | Neutrophil count (10^9/L) obtained from routine complete blood count at four time points. | Baseline (4 weeks before transplantation), pre-transplant (2 days before), during engraftment, and 2 weeks post-engraftment (approximately 10-12 weeks total follow-up). |
| Change in Lymphocyte Count | Lymphocyte count (10^9/L) obtained from routine complete blood count at four time points. | Baseline (4 weeks before transplantation), pre-transplant (2 days before), during engraftment, and 2 weeks post-engraftment (approximately 10-12 weeks total follow-up). |
| Change in Platelet Count | Platelet count (10^9/L) obtained from routine complete blood count at four time points. | Baseline (4 weeks before transplantation), pre-transplant (2 days before), during engraftment, and 2 weeks post-engraftment (approximately 10-12 weeks total follow-up). |
| Wiskemann J, Huber G. Physical exercise as adjuvant therapy for patients undergoing hematopoietic stem cell transplantation. Bone Marrow Transplant. 2008 Feb;41(4):321-9. doi: 10.1038/sj.bmt.1705917. Epub 2007 Nov 19. |
| 19597418 | Background | Baumann FT, Kraut L, Schule K, Bloch W, Fauser AA. A controlled randomized study examining the effects of exercise therapy on patients undergoing haematopoietic stem cell transplantation. Bone Marrow Transplant. 2010 Feb;45(2):355-62. doi: 10.1038/bmt.2009.163. Epub 2009 Jul 13. |
| 9345021 | Background | Dimeo F, Fetscher S, Lange W, Mertelsmann R, Keul J. Effects of aerobic exercise on the physical performance and incidence of treatment-related complications after high-dose chemotherapy. Blood. 1997 Nov 1;90(9):3390-4. |
| D005791 |
| Patient Care |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |