MyGENESIS-PATH is a self-guided digital psychoeducational intervention designed to support donor-conceived adults in managing stress and navigating identity, information, family, DNA-testing, and donor- or sibling-contact-related experiences.

This randomized pilot and feasibility trial will evaluate the feasibility and acceptability of delivering MyGENESIS-PATH and of conducting a future definitive randomized controlled trial. Sixty donor-conceived adults will be randomly allocated in a 1:1 ratio to immediate access to MyGENESIS-PATH or to a waitlist control group. The primary objectives are to assess recruitment, retention, intervention uptake and completion, data completeness, acceptability, usability, and potential unwanted effects. Changes in perceived stress, psychological wellbeing, coping, and donor-conception-related identity will be explored to assess the suitability and variability of outcome measures and to inform the design of a future trial.

MyGENESIS-PATH was developed as part of the MyGENESIS project using evidence, psychological theory, and input from donor-conceived people. Before the randomized trial, a separate alpha-testing phase will be conducted with a small group of donor-conceived adults and expert reviewers to identify major usability, comprehensibility, acceptability, technical, and safety concerns. Alpha-testing participants will not participate in the randomized trial.

The registered study is a two-arm randomized pilot and feasibility trial involving 60 donor-conceived adults. After baseline assessment, participants will be randomly allocated in a 1:1 ratio to immediate access to MyGENESIS-PATH or to a waitlist control condition.

Participants allocated to the intervention group will receive access to the self-guided digital intervention for four weeks. The intervention comprises psychoeducational modules, reflective activities, brief check-ins, and tailored coping exercises addressing donor-conception-related information and uncertainty, DNA testing, identity, expectations concerning donors and donor siblings, family relationships, disclosure, stigma, coping, and psychological wellbeing.

Participants allocated to the waitlist control group will complete the same baseline and four-week assessments and will receive access to the intervention after completing the follow-up assessment.

The study will primarily assess the feasibility and acceptability of recruitment, randomization, intervention delivery, intervention use, participant retention, and outcome-data collection. Psychological outcomes will be examined descriptively and exploratorily.

Inclusion Criteria:

• Donor-conceived people
• Aged 18 or over
• Able to read and understand English
• Provide informed consent

Exclusion Criteria:

• Not donor-conceived
• Underaged ot minor
• Unable to read and understand English
• Unable to provide informed consent
• Inability to complete online questionnaires / lack of internet access

De-identified individual participant data and supporting documentation (study protocol, statistical analysis plan, and informed consent form template) will be made available upon reasonable request to the principal investigator following publication of the primary results. Requests will be reviewed by the research team and will require a data sharing agreement and confirmation of ethical approval where applicable.

This is an open-label study. Due to the nature of the self-guided digital psychoeducational intervention, participants are aware of whether they have access to the intervention during the study period. Investigators and study personnel are not masked to allocation. Outcomes are assessed using self-report online questionnaires.