Acute sarcopenia is a rapid decline in muscle mass and function occurring within 28 days of a major stressor, such as hospitalization, infection, or surgery. It is frequent but often underdiagnosed in older adult. Current standard of care lacks systematic strategies for its early detection and risk stratification. This study therefore proposes to combine established clinical and instrumental assessments (handgrip dynamometry, bioelectrical impedance analysis, ultrasound of the anterior thigh) to better characterize the risk factors, and outcomes of acute sarcopenia in hospitalized patients aged 65 years or older.

The study hypothesis is that the use of a systematic objective clinical assessments will improve early detection and risk stratification of this condition and the detection of acute sarcopenia related outcomes.

This is a prospective observational cohort study that will be conducted in the Emergency Department and Medical Wards of the San Raffaele Hospital.

Studies objectives will include:

• Determination of the incidence of acute sarcopenia
• Identification of clinical and demographic risk factors for acute sarcopenia and relevant clinical outcomes associated with this condition

Inclusion Criteria:

• Patients aged 65 years or older.
• Hospital admission for an acute medical condition

Exclusion Criteria:

• Presence of pre-existing neuromuscular disorders.
• Diagnosis of terminal illness with life expectancy less than 30 days
• Refuse to sign written informed consent

hospitalized older people