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| Name | Class |
|---|---|
| King's College London | OTHER |
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This study aims to learn why atrial fibrillation (AF), a type of irregular heartbeat, happens more often and is harder to treat in people with hypertrophic cardiomyopathy (HCM). HCM is an inherited condition where the heart muscle is thicker than usual.
Researchers will study electrical signals from the heart and advanced heart imaging. By doing this, they hope to better understand how AF behaves in people with HCM and why treatments may not work as well for them.
The information from this study may help improve future treatments for people who have both HCM and AF.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with HCM and AF |
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| Measure | Description | Time Frame |
|---|---|---|
| Changes in bipolar voltage, conduction velocity, refractory periods and conduction divergence of the atria in patients with HCM and AF compared to patients with AF and structurally normal hearts | At the time of the clinical ablation procedure |
| Measure | Description | Time Frame |
|---|---|---|
| Correlatation between the bipolar voltage in the atria with directly measured left atrial pressure, extent of late gadolinium enhancement and ventricular extracellular volume . | At the time of clinical ablation procedure | |
| Reduction in AF inducibility in silico models following simulated ablation |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with hypertrophic cardiomyopathy and atrial fibrillation requiring atrial fibrillation ablation.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Guy's and St Thomas' NHS Foundation Trust | London | United Kingdom |
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| ID | Term |
|---|---|
| D002312 | Cardiomyopathy, Hypertrophic |
| D001281 | Atrial Fibrillation |
| ID | Term |
|---|---|
| D009202 | Cardiomyopathies |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D001020 | Aortic Stenosis, Subvalvular |
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| Based on measurements taken during the clinical ablation procedure |
| D001024 |
| Aortic Valve Stenosis |
| D000082862 | Aortic Valve Disease |
| D006349 | Heart Valve Diseases |
| D001145 | Arrhythmias, Cardiac |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |