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This study aims to detect the effect of sodium chloride 5% solution as an adjuvant treatment with antimicrobial therapy in treatment of bacterial infectious keratits and to assess whether NaCl 5% accelerates epithelial healing, improves microbial eradication, and enhances visual outcomes in bacterial infectious keratitis.
Prospective randomized control study to detect the effect of sodium chloride 5% solution as an adjuvant treatment with antimicrobial therapy in treatment of bacterial infectious keratits and to assess whether NaCl 5% accelerates epithelial healing, improves microbial eradication, and enhances visual outcomes in bacterial infectious keratitis.Data study will include two groups classified as follow : the first group will include treatment of microbial keratitis by antibiotic with sodium chloride 5% , the second group will include treatment by antibiotic only
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention group | Experimental | treatment of microbial keratitis by antibiotic with sodium chloride 5% |
|
| Control group | Active Comparator | Treatment of microbial keratitis by antibiotics only |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sodium chloride 5% solution | Drug | Use Sodium chloride 5% solution with usual anti microbial drugs |
|
| Measure | Description | Time Frame |
|---|---|---|
| Control of infection | Improvement of manifestation according to rate of healing | 6 months |
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IncluInclusion Criteria
Exclusion Criteria:
• Fungal, viral, or acanthamoeba keratitis.
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Nancy Safwat Kaldas, Specialist | Contact | 01200933440 | nansy_safwat_post@med.sohag.edu.eg | |
| Amr Mounir Mohamed, Assistant professor | Contact | 01005026170 |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Background | 9. Davidson, P.; Taylor, T. Chemical Preservatives and Natural Antimicrobial Compounds. In Food Microbiology: Fundamentals and Frontiers, 3rd ed.; Wiley Online Library: New York, NY, USA, 2017; pp. 713-745 | ||
| 31334389 | Background | Acharya M, Farooqui JH, Jain S, Mathur U. Pearls and paradigms in Infective Keratitis. Rom J Ophthalmol. 2019 Apr-Jun;63(2):119-127. | |
| 30590103 |
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| quinolones | Drug | Use of usual topical anti microbial treatment only |
|
| Background |
| Ung L, Bispo PJM, Shanbhag SS, Gilmore MS, Chodosh J. The persistent dilemma of microbial keratitis: Global burden, diagnosis, and antimicrobial resistance. Surv Ophthalmol. 2019 May-Jun;64(3):255-271. doi: 10.1016/j.survophthal.2018.12.003. Epub 2018 Dec 24. |
| ID | Term |
|---|---|
| D012965 | Sodium Chloride |
| D012996 | Solutions |
| D015363 | Quinolones |
| ID | Term |
|---|---|
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017670 | Sodium Compounds |
| D004364 | Pharmaceutical Preparations |
| D011804 | Quinolines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
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