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The "Supermarathon 2025" study was designed as a prospective, interdisciplinary field study to assess the impact of extreme physical exertion, such as a 100-kilometer ultramarathon, on the health of individuals aged ≥ 45 years. A multi-module strategy was employed, including assessment of metabolic, circulatory, respiratory, neurological, dental, psychological, and musculoskeletal functions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Amateurs runners age 45+ | Amateurs runners age 45+ who will participate in a 100km ultramarathon |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood and urine analysis | Diagnostic Test | Blood and urine analysis |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in blood and urine results | NT-proBNP in pg/ml | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. |
| Troponin I | Troponin I in ng/L | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. |
| Glucose | Glucose in mg/dl | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. |
| Insulin | Insulin in ulU/ml | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. |
| Hemoglobin A1c | Hemoglobin A1c in % | Blood samples were collected one day before the start |
| Lipid profile | LDL cholesterol, HDL cholesterol, total cholesterol and Triglicerydes in mg/dl | Blood samples were collected one day before the start |
| Creatinine kinase |
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Inclusion Criteria:
Exclusion Criteria:
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Amateur ultramarathon runners
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical University of Gdańsk | Gdansk | Poland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16534088 | Background | Warburton DE, Nicol CW, Bredin SS. Health benefits of physical activity: the evidence. CMAJ. 2006 Mar 14;174(6):801-9. doi: 10.1503/cmaj.051351. |
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Blood and urine
Creatinine kinase in U/l |
| Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. |
| Uric acid | Uric acid in mg/dl | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. |
| Vitamine D3 | Vitamine D3 in ng/ml | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. |
| Serum iron | serum iron in ug/dl | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. |
| Ferritin | Ferritin in ng/ml | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. |
| Creatinine | Creatinine in mg/dl | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. |
| Sodium | Sodium in mmol/l | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. |
| Potassium | Potassium in mmol/l | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. |
| C-reative protein | C-reractive protein in mg/l | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. |
| Liver enzymes | alanine aminotransferase, aspartate aminotransferase in U/L | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. |
| Bilirubin | Bilirubin in mg/dl | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. |
| Albumin | Albumin in g/l | Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race. |
| Cortisol in saline | Cortisol in saline in ug/dL | Saline smaples were taken one day before the race and within one hour after finishing the race |
| FSH and LH | FSH and LH | Blood samples were collected one day before the start and within 1 hour after finishing the race |
| Estradiol | Estradiol in pg/ml | Blood samples were collected one day before the start and within 1 hour after finishing the race |
| Testosterone | Testosterone in ng/dl | Blood samples were collected one day before the start and within 1 hour after finishing the race |
| SHGB | SHGB in nmol/l | Blood samples were collected one day before the start and within 1 hour after finishing the race |
| Cortisole and progestrone | Cortisole and progestrone in ng/ml | Blood samples were collected one day before the start and within 1 hour after finishing the race |
| Continuous glucose monitoring | continuous glucose monitoring using FS libre | Sensor was placed one day before the race and was measuring glucose for 14 days |
| Weight | Weight in kilograms | Measurements were taken 1 day before and within 1 hour after finishing the race |
| Height | Height in cm | Measurements were taken 1 day before the race |
| Body composition | Body composition using Tanita BC-545N - parameters in % | Measurements have been made 1 day before the race and within 1 hour after finishing the race |
| ECG | ECG measurements | Measurements have been made 1 day before the race and within 1 hour after finishing the race |
| Echocardiography | Echocardiography | Measurements have been made 1 day before the race and within 1 hour after finishing the race |
| ECG Holter | ECG Holter | ECG Holter was connected 1 day before the race and was checking heart rate and ecg within following 14 days |
| Neurological examination | Neurological examination | Examination was performed 1 day before the race and within 1 hour after finishing the race |
| Dental examination | Dental examination | Examination was performed 1 day before the race and within 1 hour after finishing the race |
| Ortophedic examination | Ortophedic examination | Examination was performed 1 day before the race and within 1 hour after finishing the race |
| Spirometry | Spirometry | Examination was performed 1 day before the race and within 1 hour after finishing the race |
| Psychological examination | Psychological examination | Examination was performed 1 day before the race and within 1 hour after finishing the race |
| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| D016482 | Urinalysis |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
| D019963 | Clinical Chemistry Tests |
| D003950 | Diagnostic Techniques, Urological |
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