Comparative Efficacy of Antibiotics for Small Intestine Bacterial Overgrowth in Bangladeshi Children

A Phase II Trial to Prevent Linear Growth Stunting and Malnutrition in Impoverished Children From a Low-Income Country by Treating Small Intestine Bacterial Overgrowth

The purpose of this Phase IIa study is to identify the most effective antibiotic regimen to treat small intestine bacterial overgrowth (SIBO) in impoverished Bangladeshi children.

Inclusion Criteria:

• Positive glucose hydrogen breath test (GHBT)
• Weight-for-age Z score > -1
• Length-for-age Z score > -1

Exclusion Criteria:

• Presence of known chronic or congenital illness, including developmental delay
• Presence of acute gastrointestinal illness in the preceding 14 days
• Antibiotic use in the preceding 14 days
• Previous adverse reaction to any of the three study medications or other drugs in the same antibiotic classes
• Sibling previously enrolled in this study