Research on Real-time Proton Therapy Guidance Through Monitoring Proton Range Using All-digital PET

Full-Digital PET Enables Real-time Monitoring of Proton Range

The energy transport process of proton beams after entering biological tissue is observed online via proton knife fully digital PET. The dynamic changes of the delivered dose and action range of proton beams in biological tissue are analyzed, the proton dose distribution is reconstructed, and the energy and position of the targeted ablation by proton beams are determined, so as to realize in-beam online PET monitoring for proton therapy.

Inclusion Criteria:

1. Patients with solid tumors scheduled to receive proton therapy, with measurable lesions;
2. Signed the informed consent form.

Exclusion Criteria:

1. Patients with a history of radioactive seed implantation;
2. Patients who cannot understand the purpose of treatment or are unwilling/unable to sign the informed consent form;