A Study to Evaluate the Efficacy of Collagen 16 Serum Alone, Against and as an Adjunct to Radiesse® Biostimulation Procedure in Female Trial Participants With Aged Skin

A Randomized Clinical Study to Evaluate the Efficacy of Collagen 16 Serum Alone, Against and as an Adjunct to Radiesse® Biostimulation Procedure in Female Trial Participants With Aged Skin

This study aims at assessing the efficacy of improving skin aging signs of a serum containing collagen 16 combined with a biostimulation device in healthy female subjects aged between 30 and 70 years over a period of 13 weeks.

Inclusion Criteria:

• Female trial participants aged from 30 to 70 years.
• Trial participants who are regular users of anti-aging cosmetic products.
• Trial participants presenting with:
• Wrinkle visibility score ≥3 and ≤6 on a 10-point visual scale.
• Fine lines visibility score ≥3 and ≤6 on a 10-point visual scale.
• Crow's feet wrinkle score ≥2 and ≤4 on the L'Oréal Atlas (volume 1 caucasian type).
• Skin radiance score ≥3 and ≤6 on a 10-point visual scale.
• Plumpness score ≥3 and ≤6 on a 10-point visual scale

Exclusion Criteria:

• Trial participants who are pregnant, breastfeeding, or planning to become pregnant during the study period.
• Trial participants who are currently participating in another facial clinical study or who have participated in such a study within 1 month that may interfere with the study outcomes.
• Trial participants presenting with current flaring or severe inflammatory acne or any active dermatological condition that, in the investigator's opinion, could interfere with study assessments.
• Trial participants who have undergone ablative laser treatments, microneedling, chemical peels, dermabrasion, non-ablative laser, intense pulsed light (IPL), or injectable procedures within the last 12 months from the day of screening.
• Trial participants who have undergone biostimulation procedures in the past 6 to 9 months from the day of screening
• Trial participants with a known allergy to any component of the investigational product(s), comparator product(s), or additional products used in the study.
• Trial participants presenting with any medical or dermatological condition that, in the investigator's opinion, may compromise trial participant safety or interfere with study conduct or evaluation.
• Trial participants who are unable or unwilling to comply with the study requirements and instructions.
• Trial participants who are unable to provide written informed consent.
• Trial participant with clinically significant history of alcoholism or drug abuse;
• Trial participant who are employees of MSCR or Sponsor