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The goal of this clinical trial is to evaluate the efficacy of adjunctive application of diode laser to mechanical, non-surgical root surface debridement in patients attending periodontal office. The main question it aims to answer is:
To compare the clinical effectiveness of adjunctive application of a 940-nm diode laser with root surface debridement to the effectiveness of root surface debridement alone.
This study is a split-mouth design, where each quadrant will be randomly allocated to one of the following groups:
Control group (root surface debridement - RsD): scaling and root planing alone. Laser group (RsD + laser): scaling and root planing with adjunctive diode laser therapy Quadrants will be randomly allocated to the treatment groups
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| test quadrants | Experimental | two contralateral jaw quadrants in each patient mouth will undergo RsD and Laser Diode assisted SRP treatment |
|
| control quadrants | Active Comparator | two contralateral jaw quadrants in each patient mouth (same patient cohort) will undergo RsD treatment only |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| LASER assisted SRP | Device | Two quadrants will be treated mechanically (ScR) with adjunctive diode laser and another two quadrants mechanically (ScR) only |
|
| Measure | Description | Time Frame |
|---|---|---|
| PPD | periodontal pocket depth | prior to treatment and 12 weeks and 6 months after treatment |
| Measure | Description | Time Frame |
|---|---|---|
| CAL | clinical attachment level | prior to treatment and 12 weeks and 6 months after the treatment |
| BOP | bleeding on probing | prior to treatment and 12 weeks and 6 months after the treatment |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mahmoud Dr Younis, DMD | Contact | +972544934823 | younisma@hotmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dr Younis Mahmoud | Recruiting | Afula | North | 1839203 | Israel |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 18724840 | Background | Schwarz F, Aoki A, Becker J, Sculean A. Laser application in non-surgical periodontal therapy: a systematic review. J Clin Periodontol. 2008 Sep;35(8 Suppl):29-44. doi: 10.1111/j.1600-051X.2008.01259.x. | |
| 31691054 | Background | Jia L, Jia J, Xie M, Zhang X, Li T, Shi L, Shi H, Zhang X. Clinical attachment level gain of lasers in scaling and root planing of chronic periodontitis: a network meta-analysis of randomized controlled clinical trials. Lasers Med Sci. 2020 Mar;35(2):473-485. doi: 10.1007/s10103-019-02875-5. Epub 2019 Nov 5. |
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no personal data will be shared and/or disclosed. only periodontal parameters collected from the medical registries will be statistically analyzed and further published in the scientific literature
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| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D010514 | Periodontal Pocket |
| D017622 | Periodontal Attachment Loss |
| ID | Term |
|---|---|
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D010518 | Periodontitis |
| D055093 | Periodontal Atrophy |
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split mouth
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| RsD | Device | mechanical root surface debridement with periodontal curettes |
|
| 9467340 | Background | Moritz A, Gutknecht N, Doertbudak O, Goharkhay K, Schoop U, Schauer P, Sperr W. Bacterial reduction in periodontal pockets through irradiation with a diode laser: a pilot study. J Clin Laser Med Surg. 1997 Feb;15(1):33-7. doi: 10.1089/clm.1997.15.33. |
| 15330944 | Background | Aoki A, Sasaki KM, Watanabe H, Ishikawa I. Lasers in nonsurgical periodontal therapy. Periodontol 2000. 2004;36:59-97. doi: 10.1111/j.1600-0757.2004.03679.x. No abstract available. |
| 24554796 | Background | Gojkov-Vukelic M, Hadzic S, Dedic A, Konjhodzic R, Beslagic E. Application of a diode laser in the reduction of targeted periodontal pathogens. Acta Inform Med. 2013 Dec;21(4):237-40. doi: 10.5455/aim.2013.21.237-240. Epub 2013 Dec 4. |
| 28945145 | Background | Matarese G, Ramaglia L, Cicciu M, Cordasco G, Isola G. The Effects of Diode Laser Therapy as an Adjunct to Scaling and Root Planing in the Treatment of Aggressive Periodontitis: A 1-Year Randomized Controlled Clinical Trial. Photomed Laser Surg. 2017 Dec;35(12):702-709. doi: 10.1089/pho.2017.4288. Epub 2017 Sep 14. |
| 23075433 | Background | Dukic W, Bago I, Aurer A, Roguljic M. Clinical effectiveness of diode laser therapy as an adjunct to non-surgical periodontal treatment: a randomized clinical study. J Periodontol. 2013 Aug;84(8):1111-7. doi: 10.1902/jop.2012.110708. Epub 2012 Oct 17. |
| 20131073 | Background | De Micheli G, de Andrade AK, Alves VT, Seto M, Pannuti CM, Cai S. Efficacy of high intensity diode laser as an adjunct to non-surgical periodontal treatment: a randomized controlled trial. Lasers Med Sci. 2011 Jan;26(1):43-8. doi: 10.1007/s10103-009-0753-5. Epub 2010 Feb 4. |
| 34163210 | Background | Pawelczyk-Madalinska M, Benedicenti S, Salagean T, Bordea IR, Hanna R. Impact of Adjunctive Diode Laser Application to Non-Surgical Periodontal Therapy on Clinical, Microbiological and Immunological Outcomes in Management of Chronic Periodontitis: A Systematic Review of Human Randomized Controlled Clinical Trials. J Inflamm Res. 2021 Jun 15;14:2515-2545. doi: 10.2147/JIR.S304946. eCollection 2021. |
| 34327566 | Background | Jia L, Jia J, Wu M, Li T, Zhao C, Shi H, Zhang X. Probing depth reduction of laser application in periodontal therapy: a network meta-analysis. Lasers Med Sci. 2022 Mar;37(2):1217-1226. doi: 10.1007/s10103-021-03376-0. Epub 2021 Jul 29. |
| 34962665 | Background | Gur AT, Guncu GN, Akman AC, Pinar A, Karabulut E, Nohutcu RM. Evaluation of GCF IL-17, IL-10, TWEAK, and sclerostin levels after scaling and root planing and adjunctive use of diode laser application in patients with periodontitis. J Periodontol. 2022 Aug;93(8):1161-1172. doi: 10.1002/JPER.21-0494. Epub 2022 Jan 25. |
| 34733760 | Background | Mokhtari MR, Ahrari F, Dokouhaki S, Fallahrastegar A, Ghasemzadeh A. Effectiveness of an 810-nm Diode Laser in Addition to Non-surgical Periodontal Therapy in Patients With Chronic Periodontitis: A Randomized Single-Blind Clinical Trial. J Lasers Med Sci. 2021 Jul 19;12:e37. doi: 10.34172/jlms.2021.37. eCollection 2021. |
| 37219608 | Background | Lu JW, Huang SH, Lei XX, Deng L, Luo LJ. Clinical outcomes of diode laser as an adjunct to nonsurgical periodontal therapy for residual periodontal pockets in mandibular second molars-a randomized controlled clinical trial. Clin Oral Investig. 2023 Aug;27(8):4493-4501. doi: 10.1007/s00784-023-05071-6. Epub 2023 May 23. |
| 35155153 | Background | Alizadeh Tabari Z, Pournasir L, Mohammadreza S, Anbari F. Clinical Efficacy of the 940-nm Diode Laser in the Treatment of Recurrent Pockets in the Periodontal Maintenance Phase. J Lasers Med Sci. 2021 Nov 6;12:e68. doi: 10.34172/jlms.2021.68. eCollection 2021. |