• Endovenous RFA Versus Ligation and Striping for Varicose Veins

  NCT04526626

  Unknown statusInterventionalNot ApplicableUpdated Aug 26, 2020
• Comparison of Radiofrequency, Vein Stripping and CHIVA for Venous Insufficency

  NCT02454452

  CompletedInterventionalNot ApplicableUpdated Aug 22, 2017
• Comparison of Treatments in Venous Insufficiency

  NCT01298908

  CompletedInterventionalNot ApplicableUpdated Jan 8, 2016
• Radio Frequency Ablation Versus Stripping of Great Saphenous Vein in Management of Primary Varicose Veins , Comparative Study

  NCT05342779

  Unknown statusInterventionalNot ApplicableUpdated Apr 25, 2022
• Prospective Randomized Trial Comparing the New Endovenous Procedures Versus Conventional Surgery for Varicose Veins Due to Great Saphenous Vein Incompetence

  NCT00621062

  CompletedInterventionalNot ApplicableUpdated Feb 3, 2014
• Radiofrequency Ablation vs. Laser Ablation of the Incompetent Small Saphenous Vein

  NCT02248740

  TerminatedInterventionalPhase 4Updated Feb 7, 2019

ClinicalTrials.gov ID

NCT07445425

Lead Sponsor

Sir Run Run Shaw HospitalOTHER

Overall Status

Not yet recruiting

Study Type

Interventional

Phase

Not Applicable

Enrollment

206Estimated

Last Update Posted

Mar 3, 2026Actual

Start Date

Mar 2026Estimated

Primary Completion Date

Dec 2026Estimated

Completion Date

Dec 2026Estimated

Official Title

Comparison of Concomitant or Staged Treatment of Tributary Veins for Lower Extremity Varicose Veins: A Multicenter Randomized Controlled Study

Brief Summary

The purpose of this clinical trial is to know which is better to treat the branch vein at the same time or in stages during radiofrequency ablation. The main questions it aims to answer are:

Does the patient who did not treat the branch vein in the first stage of operation need to intervene again? Are there any differences in patients' indexes between the two surgical strategies?

Participants will:

Radiofrequency ablation with or without foam sclerosing agent therapy One week, three months and six months after operation, go to the clinic for a reexamination.

Record their symptoms

• Varicose Veins of Lower Limb

• Staged surgery group
• Concomitant surgery group

Ages Eligible for Study

Adult (18-64)Older Adult (65+)

Sexes Eligible for Study

All

Accepts Healthy Volunteers

Yes

Eligibility Criteria

Inclusion Criteria:

aged between 18 and 80 years; primary unilateral lower limb GSV varicose; hemodynamic classification I and III involvement in tributary veins, tributary veins originating within 15 cm inferior to the knee joint; clinical grade C2-C4; primary trunk diameter of GSV in thigh segment≥3mm to ≤ 15 mm; agree to participate in this study and voluntarily sign an informed consent form.

Exclusion Criteria:

Body Mass Index (BMI) ≥35kg/m2; severe tortuosity or tight adherence of the trunk of the GSV to the skin in the thigh; history of previous varicose vein surgery on the ipsilateral lower limb (investigator allows to be controlled); previous deep vein thrombosis and/or calf muscle venous thrombosis; uncorrectable coagulation disorders or significant blood abnormalities (platelets≤30×109/L); allergy to lidocaine or sclerosing agents; ankle-brachial index (ABI) <0.6 and/or absolute ankle pressure <60mmHg; pregnancy or lactation, or intend to have a child in the next year; participation in other clinical trials; anterior saphenous vein start diameter>3.5mm; any other patients investigator considers improper to participate in this study.

Primary Purpose

Treatment

Allocation

Randomized

Interventional Model

Parallel Assignment

Masking

Single

Lead Sponsor

Sir Run Run Shaw HospitalOTHER

8618851258521

8613053420366

8618653587355

8613156987626

13777831991