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Preeclampsia with severe features remains a leading contributor to maternal morbidity and mortality, particularly in low- and middle-income countries. It is defined by hypertension and involvement of multiple organ systems, including renal, hepatic, hematologic, and neurologic pathways. The interplay of endothelial dysfunction, capillary leakage, and disrupted fluid balance in these patients increases their susceptibility to perioperative pulmonary complications. Although respiratory complications in preeclampsia are clinically significant, the true incidence of postoperative diaphragmatic dysfunction in women with severe disease is not well established. Existing literature largely emphasizes general respiratory failure, pulmonary edema, or the need for mechanical ventilation, rather than specifically evaluating diaphragmatic performance with objective methods such as ultrasound. The current study sought to determine the incidence and identify risk factors for postoperative diaphragmatic dysfunction in women with severe preeclampsia following cesarean delivery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Preeclampsia with severe features | diaphragmatic excursion evaluation |
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| Measure | Description | Time Frame |
|---|---|---|
| The incidence of postoperative diaphragmatic dysfunction | diaphragmatic dysfunction is defined as a mean diaphragmatic excursion of less than 10 mm | Diaphragmatic excursion is measured before and 24 hours after surgery. |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of change in DE | Percentage of change in diaphragmatic excursion from baseline to 24 hours after surgery | 24 hours after surgery |
| Risk factors associated with postoperative diaphragmatic dysfunction |
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Inclusion Criteria:
Exclusion Criteria:
• Age < 20 years.
This prospective observational study will enroll pregnant women aged 20-40 years present to the emergency department with a diagnosis of preeclampsia with severe features and are scheduled for cesarean delivery
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mina Adolf Helmy, MD | Contact | 01275716942 | minaadolf1988@cu.edu.eg |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cairo University Hospitals | Recruiting | Cairo | Egypt |
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| ID | Term |
|---|---|
| D011225 | Pre-Eclampsia |
| ID | Term |
|---|---|
| D046110 | Hypertension, Pregnancy-Induced |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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Regression analysis to detect risk factors
| 24 hours after surgery |