Optimized Strict Fluid Management Helps Improve Endpoints After Liver Dissection

The Effect of Different Fluid Therapy on Major Postoperative Morbidity in Patients Undergoing Non-donor Hepatectomy: a Pilot Trial

During hepatectomy, surgeons often prefer to restrict fluid intake, believing that this can lower central venous pressure (CVP) and reduce intraoperative blood loss. However, fluid restriction may lead to inadequate perfusion of vital organs and even contribute to postoperative organ dysfunction, such as acute kidney injury (AKI). Therefore, this study aims to compare the effects of restrictive versus liberal fluid therapy on major complications following hepatectomy.

Inclusion Criteria:

• scheduled for elective hepatectomy under general anesthesia
• age ≥18 yrs old

Exclusion Criteria:

• American society of anesthesiologists status over 3
• existed kidney disease or renal dysfunction
• severe cardiac or respiratory dysfunction
• neurological or psychiatric disease
• Child-Pugh class C (score 10-15)