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The goal of this observational study is to learn about the risk factors and prediction of postoperative venous thromboembolism (VTE) in patients undergoing lung cancer surgery. The main question it aims to answer is:
Which clinical, surgical, and laboratory factors are associated with the development of postoperative deep vein thrombosis (DVT) in lung cancer surgery patients, and can machine learning models accurately predict individual risk?
Participants undergoing lung cancer surgery will be prospectively followed for 30 days after surgery. Perioperative clinical data, laboratory results, and imaging findings will be collected to identify VTE risk factors and to develop a predictive model.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| VTE Group | Adult patients undergoing lung cancer surgery who develop postoperative deep vein thrombosis (DVT) within 30 days. Perioperative clinical, laboratory, and imaging data will be collected to identify risk factors and build predictive models. |
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| Non-VTE Group | Adult patients undergoing lung cancer surgery who do not develop postoperative DVT within 30 days. Perioperative clinical, laboratory, and imaging data will be collected for comparison with the VTE group. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Prospective Perioperative Data Collection | Other | The intervention involves the prospective collection of perioperative clinical, laboratory, and imaging data from adult patients undergoing lung cancer surgery. No therapeutic or diagnostic procedures beyond standard care are applied. Collected data will be used to identify risk factors for postoperative deep vein thrombosis (DVT) and to develop machine learning-based predictive models. |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of postoperative deep vein thrombosis (DVT) in lung cancer surgery patients | The primary outcome is the occurrence of postoperative deep vein thrombosis (DVT) within 30 days after lung cancer surgery, confirmed by Doppler ultrasound of the lower extremities. Perioperative clinical, laboratory, and imaging variables will be collected prospectively and analyzed to identify risk factors and develop machine learning-based predictive models for individual DVT risk. | From the day of lung cancer surgery to 30 days postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| Identification of perioperative risk factors for postoperative deep vein thrombosis (DVT) in lung cancer surgery patients | Secondary outcomes include the evaluation of clinical, surgical, and laboratory variables associated with postoperative DVT within 30 days. Variables such as age, sex, BMI, comorbidities, tumor characteristics, operative details, and perioperative laboratory results will be analyzed using multivariate logistic regression and machine learning models to identify independent predictors of DVT. |
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Inclusion Criteria:
Exclusion Criteria:
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The study population consists of adult patients undergoing surgical resection for lung cancer at the Department of Thoracic Surgery, First Hospital of Jilin University. Participants will be prospectively followed for 30 days postoperatively to assess the occurrence of deep vein thrombosis (DVT) and to identify perioperative risk factors. All patients meeting inclusion criteria and without exclusion criteria will be eligible.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Wei Liu | Contact | 86-13596083366 | l_w01@jlu.edu.cn |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The First Hospital of Jilin University, Department of Thoracic Surgery | Recruiting | Changchun | Jilin | 130021 | China |
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| ID | Term |
|---|---|
| D008175 | Lung Neoplasms |
| D004194 | Disease |
| D020246 | Venous Thrombosis |
| D054556 | Venous Thromboembolism |
| ID | Term |
|---|---|
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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|
| From the day of surgery to 30 days postoperatively |
| D008171 |
| Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D013927 | Thrombosis |
| D016769 | Embolism and Thrombosis |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D013923 | Thromboembolism |