The purpose of this study is to assess the safety and tolerability of ORN252 in healthy adult participants.

Inclusion Criteria:

• Male and female participants who are healthy as determined by the Investigator based on review of medical history, physical examination, and laboratory tests
• Participant is willing and able to comply with study visits and other protocol requirements
• Other protocol specific inclusion criteria may apply

Exclusion Criteria:

• Clinically significant history or presence of organ dysfunction
• Use of any investigational product within 3 months, or 5 half-lives, whichever longer
• Other protocol specific exclusion criteria may apply