To investigate the efficacy, safety, and compliance of a simplified strategy using vonoprazan plus clarithromycin for first-line treatment in patients with Helicobacter pylori infection, among those infected with strains without clarithromycin resistance gene mutations based on fecal clarithromycin resistance gene detection.

Inclusion Criteria:

1. Aged 18-70 years;
2. Positive results for both ¹³C-urea breath test (¹³C-UBT) and fecal polymerase chain reaction (PCR), confirming Helicobacter pylori infection, with a clinical indication for H. pylori eradication as judged by the physician;
3. Treatment-naïve individuals with no prior history of H. pylori eradication therapy.

Exclusion Criteria:

1. Pregnant or lactating women
2. Patients with a history of allergy to any drugs used in the eradication regimen
3. Patients with severe systemic diseases or malignant tumors
4. History of gastric resection surgery
5. Recent use of antibiotics or bismuth salts (within 4 weeks), H₂-receptor antagonists, proton pump inhibitors (PPIs), or Potassium-competitive acid blockers(P-CABs) (within 2 weeks).