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The study aimed to evaluate the effect of Hyaluronic Acid-based gel use in addition to the coronally advanced flap (CAF) technique in type 1 gingival recession (RT1) on postoperative morbidity, clinical parameters, and patient satisfaction, analyzed at baseline and 6 months.
The aim of this study is to evaluate the effect of HA use in addition to the coronally advanced flap (CAF) technique in type 1 gingival recession (RT1) on postoperative morbidity, clinical parameters, and patient satisfaction, analyzed at baseline and 6 months.
This split-mouth study included 20 patients (9 males, 11 females) with a mean age of 42.10±9.46 years who were diagnosed with bilateral RT1 gingival recession in the maxilla. The right and left defect areas of the 20 patients were randomly assigned to two groups. The control group received CAF (n=20), and the test group received CAF+HA (n=20). Pre-treatment plaque index (PI), gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL), vertical recession depth (VRD), horizontal recession width (HRW), gingival thickness (GT), attached gingival (AG), and keratinized gingival width (KGW) were recorded. Additionally, a satisfaction analysis was conducted, including patient-based comfort (PBC), aesthetic (PEA), and sensitivity (PHS) scores. During the operation, a 0.8% HA gel was applied to the defect areas in the test group, in addition to CAF, while saline was applied to the control group, also in addition to CAF. Pain, bleeding, and edema scores, as well as the amount of painkillers, were recorded during the 9-day postoperative period. Clinical parameter measurements and patient satisfaction analyses were repeated 6 months after surgical treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Coranally Advanced Flap and Hyaluronic Acid-Based Gel application | Active Comparator | Coronally advanced flap and adjunctive use of 0.8% hyaluronic acid-based gel |
|
| Coranally Advanced Flap | Placebo Comparator | Only Coronally advanced flap |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hyaluronic acid | Drug | 0.8% hyaluronic acid gel (Gengigel Oral Forte Gel, Ricefarma, Milan, Italy) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Complete root coverage | for evaluating rate of complete root coverage | 6 months postsurgery |
| Mean root coverage | for evaluating rate of mean root coverage | 6 months postsurgery |
| Measure | Description | Time Frame |
|---|---|---|
| Plaque Index | to assess plaque accumulation | Baseline |
| Plaque Index | to assess plaque accumulation | 6 months post surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Figen Öngöz Dede, Prof | Ordu Universitesi | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Figen Öngöz Dede | Ordu | 52100 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D005889 | Gingival Recession |
| ID | Term |
|---|---|
| D005882 | Gingival Diseases |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D006820 | Hyaluronic Acid |
| ID | Term |
|---|---|
| D006025 | Glycosaminoglycans |
| D011134 | Polysaccharides |
| D002241 | Carbohydrates |
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| Steril saline solution | Other | Mix 8 teaspoons of salt into 4 L of distilled water |
|
| Gingival Index | for evaluating gingival inflammation | Baseline |
| Gingival index | for evaluating gingival inflammation | 6 montsh post surgery |
| Probing pocket depth | for measuring disease severity | Baseline |
| Probing pocket depth | for measuring disease severity | 6 months post surgery |
| Clinical attachment level | Clinical attachment level (CAL) is calculated by adding or subtracting probing depth (PD) and gingival recession (GR). The formula is CAL = PD + GR. CAL is measured in millimeters. | Baseline |
| Clinical attachment level | Clinical attachment level (CAL) is calculated by adding or subtracting probing depth (PD) and gingival recession (GR). The formula is CAL = PD + GR. CAL is measured in millimeters. | 6 months post surgery |
| Vertical recession depth | for evaluating gingival recession depth | Baseline |
| Vertical recession depth | for evaluating gingival recession depth | 6 months postsurgery |
| Horizontal gingival recession | for evaluating gingival recession depth | Baseline |
| Horizontal gingival recession | for evaluating gingival recession depth | 6 months postsurgery |
| Attached gingival width | for evaluating attached gingival width | Baseline |
| Attached gingival width | for evaluating attached gingival width | 6 months postsurgery |
| Keratinized gingival width | for evaluating keratinized gingival width | Baseline |
| Keratinized gingival width | for evaluating keratinized gingival width | 6 months postsurgery |
| Gingival thickness | for evaluating gingival thickness | Baseline |
| Gingival thickness | for evaluating gingival thickness | 6 months postsurgery |
| Patient comfort score | Patient satisfaction was assessed using a visual analog scale (VAS). "unbearable discomfort (score 0)" to "no discomfort (score 10)". | Baseline |
| Patient comfort score | Patient satisfaction was assessed using a visual analog scale (VAS). "unbearable discomfort (score 0)" to "no discomfort (score 10)". | 6 months postsurgery |
| Patient aesthetic score | Poor-unexpected aesthetics (score 0) → beautiful-perfect aesthetics (score 10) using VAS scale | Baseline |
| Patient aesthetic score | Poor-unexpected aesthetics (score 0) → beautiful-perfect aesthetics (score 10) using VAS scale | 6 months post surgery |
| Patient sensitivity score | painless-discomfort no (score 0) → unbearable pain (score 10) using VAS scale | Baseline |
| Patient sensitivity score | painless-discomfort no (score 0) → unbearable pain (score 10) using VAS scale | 6 months postsurgery |
| D055093 |
| Periodontal Atrophy |