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Proximal femoral fractures are associated with increased mortality in older adults and may contribute to loss of functional independence, resulting in a higher risk of long-term institutionalization. The SIOT 2021 guidelines emphasize that management of older patients with proximal femoral fracture (FPF) requires a multidisciplinary approach, ideally integrated across all phases of care, including rehabilitation and secondary prevention at the community level, according to a continuity-of-care model that incorporates the implementation of Fracture Liaison Services.
Multiple clinical, social, and environmental factors influence fall risk. Falls are also associated with psychological consequences. Age-related reductions in muscle strength contribute to progressive functional decline, increased morbidity and mortality related to falls, reduced quality of life, depression, and hospitalization.
Sarcopenia is characterized by both quantitative and qualitative reductions in muscle tissue, including progressive replacement of contractile tissue with fibrous and adipose tissue. The European Working Group on Sarcopenia in Older People (EWGSOP), in its updated consensus (EWGSOP2), identifies low muscle strength as the primary parameter of sarcopenia, accompanied by a significant and generalized reduction in muscle mass.
A use-case model dedicated to patients with sarcopenia describes typical demographic and social characteristics, associated comorbidities, and specific care needs, with the aim of identifying the most appropriate management pathways.
This study adopts a person-centered approach to design, validate, and implement an integrated strategy for fall prevention, taking into account the multiple determinants of fall risk and related adverse health outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| evaluation of strength and endurance training in patients with risk of falls and sarcopenia, assesse |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Khymeia | Device | All patients will undergo specific rehabilitation training for fall risk prevention and will be assessed twice at To and T1. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Balance Measurement | Participant balance assessed using standardized clinical tests. | 2 months |
| Measure | Description | Time Frame |
|---|---|---|
| Joint Range of Motion (Degrees) | Measured in degrees using goniometry | two months |
| SARC-F Score for Sarcopenia Screening | Total score 0-10; score >4 indicates probable sarcopenia. |
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Inclusion Criteria
Age ≥ 65 years at the time of enrollment
Radiographically confirmed knee osteoarthritis or hip osteoarthritis classified as Kellgren-Lawrence grade 2 or 3
Clinical indication for structured rehabilitation therapy
Diagnosis of sarcopenia according to European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria, defined as:
Low muscle strength (handgrip strength < 27 kg in men or < 16 kg in women, or chair stand test > 15 seconds for 5 rises), and
Reduced muscle mass confirmed by a validated assessment method (e.g., dual-energy X-ray absorptiometry [DXA] or bioelectrical impedance analysis [BIA]) according to established cut-off values
Exclusion Criteria
Absolute contraindication to rehabilitation therapy as determined by the treating physician
Hemodynamic instability, including uncontrolled arrhythmias, symptomatic hypotension, or acute coronary syndrome within the previous 3 months
Unstable fractures
Severe open wounds or lacerated-contused injuries requiring surgical management
Severe cognitive impairment preventing participation in rehabilitation activities (e.g., Mini-Mental State Examination score < 18)
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elderly>65 years with higher fall risk
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Rossana Gnasso, Researcher | Contact | +39 3935360702 | rossana.gnasso@unina.it | |
| Antonio Picone, PhD | Contact | +39 3398780254 | antonio.picone@unina.it |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Federico II of Naples, Department of Public Health | Naples | Napoli | 80131 | Italy |
Individual participant data will not be shared. Study results will be disseminated through scientific publications and presentations
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| ID | Term |
|---|---|
| D055948 | Sarcopenia |
| ID | Term |
|---|---|
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| two months |
| Romberg Test Balance Time (Seconds) | Time in seconds maintaining balance. | two months |
| Pain Intensity Measured by Numeric Rating Scale (0-10) | Scale 0-10; 0 = no pain, 10 = worst pain. | two months |
| Short Physical Performance Battery (SPPB) Total Score | Total score 0-12; lower scores indicate poorer physical performance. | two months |
| Quality of Life Scale (QOLS) Total Score | 17-item questionnaire; higher scores indicate better quality of life. | two months |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |