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The goal of this observational study is to describe speech and breathing patterns in adults after acquired brain injury (ABI) and understand how these patterns relate to the presence, severity, and type of dysarthria. The main questions it aims to answer are:
Participants will:
About 97 to 101 participants will take part. The results will help speech therapists better detect, evaluate, and treat dysarthria in adults after brain injury.
This cross-sectional observational study aims to characterise acoustic, respiratory, and clinical speech parameters in adults with acquired brain injury (ABI) and to examine their associations with the presence and severity of dysarthria. The study is limited to baseline assessment and does not include therapeutic intervention or longitudinal follow-up.
Participants complete a standardised evaluation protocol conducted in a controlled clinical setting. All assessments are performed within a short and predefined evaluation period to minimise fatigue and contextual variability. The protocol comprises three assessment sessions: (1) acoustic and aerodynamic speech evaluation based on sustained phonation vowels /a/, /i/, /u/, /o/ and connected speech tasks; (2) objective assessment of respiratory function using spirometry; and (3) clinical assessment of dysarthria using the Frenchay Dysarthria Assessment-2 (FDA-2).
Speech recordings are obtained under standardised conditions to ensure consistency across participants and reliable extraction of acoustic measures. Respiratory assessments are performed according to established international guidelines to ensure validity and reproducibility. Data from acoustic, respiratory, and clinical assessments are analysed jointly to explore associations between phonorespiratory function and dysarthria severity in adults with ABI.
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| Measure | Description | Time Frame |
|---|---|---|
| Dysarthria severity assessed by the Frenchay Dysarthria Assessment-2 (FDA-2) | Severity of dysarthria assessed using the Frenchay Dysarthria Assessment-2 (FDA-2), reported as a total score reflecting overall speech motor impairment. Unit of Measure: FDA-2 total score (ordinal scale) | Baseline |
| Vowel Space Area (VSA) | Vowel Space Area calculated from the first and second formant frequencies (F1-F2) of the corner vowels (/i/, /a/, /u/), expressed in kHz², reflecting articulatory working space and articulatory precision. | Baseline |
| Formant Centralization Ratio (FCR) | Formant Centralization Ratio derived from mean formant frequencies of the vowels (/a, e, i, o, u/), expressed as a dimensionless ratio, reflecting vowel centralization and articulatory impairment. | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Median Fundamental Frequency (F₀) | Median fundamental frequency (F0) of sustained /a/ vowel phonation, expressed in Hertz (Hz). | Baseline |
| Jitter | Short-term frequency perturbation of sustained /a/ vowel phonation, expressed as a percentage (%). |
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Inclusion Criteria:
Diagnosed with acquired brain injury (ABI), including:
Exclusion Criteria:
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The study population will include adult participants aged 18 years or older with a diagnosis of acquired brain injury (ABI), including stroke, traumatic brain injury, or brain tumor. Participants will be recruited from hospitals, clinics, and patient associations in Salamanca, Spain. Both individuals with and without dysarthria secondary to ABI will be included. All participants must have preserved cognitive function (Mini-Mental State Examination score ≥ 24) and be able to provide written informed consent or have a legally authorized representative provide consent if necessary.
Participants with chronic respiratory diseases, significant hearing impairments, additional neurological or neurodegenerative disorders, pre-existing voice disorders, severe aphasia, or persistent pharyngeal symptoms will be excluded.
The sample size is estimated to be between 97 and 150 participants, considering a dysarthria prevalence of 60% in the ABI population, a 95% confidence level, and a margin of err
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| AHMED ARGOUBI, Speech Language Pathologist | Contact | +34 652555591 | ahmedargoubi@usal.es | |
| Ana-María Martín-Nogueras, Investigator/ Profesor | Contact | +34 669284767 | anamar@usal.es |
| Name | Affiliation | Role |
|---|---|---|
| Ana-María Martín Nogueras, Investigator/ Profesor | University of Salamanca | Principal Investigator |
| Ana-María Martín Nogueras | University of Salamanca | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Salamanca | Recruiting | Salamanca | Salamanca | 34007 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42049296 | Derived | Argoubi A, Diez Garcia R, Hernandez Moreda B, Martin-Nogueras AM. Integrated acoustic and respiratory biomarkers of dysarthria in acquired brain injury: protocol for a cross-sectional study. BMJ Open. 2026 Apr 28;16(4):e115669. doi: 10.1136/bmjopen-2025-115669. |
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| ID | Term |
|---|---|
| D004401 | Dysarthria |
| D001930 | Brain Injuries |
| D003147 | Communication Disorders |
| D014832 | Voice Disorders |
| ID | Term |
|---|---|
| D001184 | Articulation Disorders |
| D013064 | Speech Disorders |
| D007806 | Language Disorders |
| D019954 | Neurobehavioral Manifestations |
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| Baseline |
| Shimmer | Short-term amplitude perturbation of sustained /a/ vowel phonation, expressed as a percentage (%). | Baseline |
| Harmonics-to-Noise Ratio (HNR) | Ratio between noise and harmonic components of the sustained /a/ vowel phonation, expressed in decibels (dB). | Baseline |
| Maximum Phonation Time (MPT) | Maximum duration of sustained vowel phonation (/a/) measured during a standardized task, expressed in seconds (s). | Baseline |
| Maximum Emission Time (MET) | Maximum duration of sustained fricative emission measured during a standardized task, expressed in seconds (s). | Baseline |
| s/z Ratio | Ratio between maximum sustained durations of voiceless (/s/) and voiced (/z/) fricative emissions, expressed as a dimensionless ratio. | Baseline |
| Vital Capacity (VC) | Vital capacity measured by standard spirometry, defined as the maximum volume of air exhaled following a maximal inhalation, expressed in litres (L). | Baseline |
| Forced Vital Capacity (FVC) | Forced vital capacity measured by standard spirometry during a forced expiratory manoeuvre, expressed in litres (L). | Baseline |
| Forced Expiratory Volume in One Second (FEV₁) | Forced expiratory volume in the first second measured by standard spirometry, expressed in litres (L). | Baseline |
| Maximum Voluntary Ventilation (MVV) | Maximum voluntary ventilation measured by standard spirometry during rapid and deep breathing, expressed in litres per minute (L/min). | Baseline |
| FEV₁/FVC Ratio | Ratio between forced expiratory volume in one second and forced vital capacity, expressed as a percentage (%). | Baseline |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D006259 | Craniocerebral Trauma |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
| D007818 | Laryngeal Diseases |
| D012140 | Respiratory Tract Diseases |
| D010038 | Otorhinolaryngologic Diseases |