The goal of this clinical trial is to compare post-treatment pain after root canal therapy in adults with irreversible pulpitis using different root canal sealers. The study will also evaluate the need for pain medication after treatment.

The main questions this study aims to answer are:

Does the type of root canal sealer affect the intensity of pain after treatment?

Does the type of sealer influence the number of analgesic tablets taken by participants?

How does pain change over time after treatment with different sealers?

Researchers will compare two bioceramic sealers (EndoSeal TCS and NeoSeal) with a resin-based sealer (AH Plus) to determine their effects on post-endodontic pain.

Participants will:

Receive root canal treatment using one of the study sealers

Report their pain intensity at specific time points after treatment

Record the number of analgesic tablets taken during the follow-up period

Inclusion Criteria:

• Age between 18 and 60 years
• Adequate oral and dental hygiene
• Prolonged positive response to cold test and electric pulp testing
• Clinical diagnosis of symptomatic irreversible pulpitis and symptomatic apical periodontitis in a first or second molar (maxillary or mandibular)
• Pulp exposure during caries removal accompanied by severe and profuse hemorrhage
• No radiographic evidence of periapical lesions
• Teeth with adequate restorative potential
• Absence of periodontal disease

Exclusion Criteria:

• Teeth that are non-restorable
• Presence of endodontic-periodontal (endo-perio) lesions
• Teeth with radiographic evidence of periapical lesions
• Teeth with internal or external root resorption
• Patients with systemic diseases classified as ASA II or higher
• Patients with a history of migraine
• Teeth with over-obturation or under-obturation greater than 2 mm from the radiographic apex
• Patients taking anti-anxiety medications
• Procedural duration exceeding two hours
• Known allergy to materials used in root canal treatment, including local anesthetics