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The current study serves as a pilot for the GRF project "Predicting illness trajectories in fully remitted major depression using concurrent TBS/fNIRS." The project examines whether intermittent theta-burst stimulation (iTBS) induces immediate changes in prefrontal excitability in healthy individuals, compared to sham stimulation. In this randomized, sham-controlled trial, investigators will assess several psychological measures-including the Perceived Stress Scale and the Coping Inventory for Stressful Situations-to explore how stress levels and coping strategies relate to immediate prefrontal cortex (PFC) activity changes following TBS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Real Stimulation | Active Comparator | Participants in this arm will receive a real session of iTBS over the left dorsolateral prefrontal cortex |
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| Sham Stimulation | Sham Comparator | Participants in this arm will receive a sham session of iTBS over the left dorsolateral prefrontal cortex |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcranial Magnetic Stimulation | Device | sham stimulation protocols is to mimic the sensations experienced by participants during active stimulation, without stimulating the brain |
| Measure | Description | Time Frame |
|---|---|---|
| iTBS induced prefrontal cortex activity and connectivity | 3 minutes before, during, and after the stimulation |
| Measure | Description | Time Frame |
|---|---|---|
| perceived stress scale | the same day before conducting the experiment | |
| coping inventory for stressful situations | the same day before conducting the experiment |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Hong Kong Polytechnic University | Hong Kong | 九龙 | China |
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| ID | Term |
|---|---|
| D050781 | Transcranial Magnetic Stimulation |
| ID | Term |
|---|---|
| D055909 | Magnetic Field Therapy |
| D013812 | Therapeutics |
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