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The goal of this clinical trial is to learn if an 8-week, community-based pickleball program can improve sensory-motor function and reduce the severity of core autism symptoms in adults ages 18-45 with autism spectrum disorder (ASD) who can participate independently without a caregiver.
The main questions it aims to answer are:
Researchers will compare an early-start pickleball group to a delayed-start control group (who continues usual activities at first) to see if the pickleball program leads to greater improvements in sensory-motor outcomes and ASD symptom severity.
Participants will:
Autism spectrum disorder (ASD) is associated with sensory-motor impairments that can impact everyday functioning. Prior research suggests that disrupted visual-motor integration and altered sensory weighting (e.g., greater reliance on proprioceptive input relative to visual input) may relate to the severity of core autism symptoms. The current study evaluates whether a structured, community-based pickleball program can serve as a practical and scalable behavioral intervention to modify these sensory-motor mechanisms and improve outcomes in autistic adults.
Study Design
This study is a two-arm, parallel-group, delayed controlled trial (DCT) evaluating the effects of an 8-week pickleball intervention delivered in a community setting. Participants complete baseline testing and are randomized 1:1 to either:
Phase 1 is structured as the randomized comparison period. All participants complete post-testing at the end of Phase 1. The delayed group then receives the intervention during Phase 2. This design allows both a controlled between-group comparison during Phase 1 and a within-subject evaluation of change across all participants once they receive the intervention.
The study is planned to occur between February and May 2026, with assessments occurring at defined pre- and post-intervention timepoints.
Intervention Overview (Pickleball Program) The intervention consists of twice-weekly pickleball sessions for 8 weeks (16 sessions total). Each session lasts approximately 90 minutes and is delivered at indoor community court facilities with trained instructors. At least one study team member is present, along with undergraduate research assistants, to support implementation and monitoring.
Each session follows a standardized structure:
The class is designed to be beginner-friendly and self-paced, with built-in opportunities for rest and hydration. Participants may stop or rest as needed.
Testing Visits and Assessments Participants complete a structured series of assessments at baseline and follow-up timepoints. Data collection includes physical measurements, survey measures, and behavioral/motor testing. Testing procedures occur in-person at community-based testing locations selected to reduce access barriers. Written informed consent is obtained at the testing visit before any study procedures occur.
Sensory-Motor Function Assessment (Primary Outcome Domain)
Sensory-motor outcomes are assessed using two primary approaches:
Autism Symptom Severity (Primary Outcome Domain) Core ASD symptom severity is assessed using the Social Responsiveness Scale, 2nd edition (SRS-2), adult self-report form. The primary symptom endpoint is the SRS-2 total score.
Secondary Outcomes
Secondary outcomes include self-reported measures of mental health and quality of life:
Physical Activity Monitoring (In-Session) To characterize activity levels during the intervention, wearable actigraphy (ActiGraph) is used to monitor movement intensity during pickleball classes on a bimonthly basis. The device is worn around the waist during class sessions and passively records movement without collecting audio, video, or location information.
Safety and Acceptability Monitoring Participants currently receiving the pickleball intervention complete brief bimonthly online check-ins (via REDCap) to monitor pain/injury and provide structured qualitative feedback.
Study Groups and Assessment Schedule
The delayed-control structure results in different assessment schedules depending on group assignment:
In addition, the protocol allows continued enrollment during Phase 1 so that "late enrolled" participants can complete Phase 2 intervention participation and contribute to within-subject pre/post analyses, though not to the randomized Phase 1 comparison.
Sample Size and Accrual The study plans to enroll up to 50 participants to account for screen failures and attrition, with an expected completed sample of approximately 30-35 participants.
Planned Analytic Approach The study is designed to estimate the potential effectiveness of the pickleball program by comparing pre-to-post changes in primary and secondary outcomes. The Phase 1 randomized component supports a between-group comparison of change scores during the controlled period, while the delayed-start design also supports within-subject change analyses across participants who complete the intervention.
Study Setting Testing is conducted in community-based locations near the intervention sites to reduce participation barriers. Pickleball sessions are conducted at indoor community recreation facilities.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Early Start Pickleball (Intervention) | Experimental | Participants assigned to this arm begin the community-based pickleball program immediately after baseline testing. They participate in supervised pickleball classes twice per week for 8 weeks (16 sessions total). Assessments are completed at baseline and after the Phase 1 intervention period. Participants then return to usual activities during Phase 2 and complete a follow-up assessment. |
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| Delayed Start (Waitlist/Usual Activity Control) | Other | Participants assigned to this arm continue their usual activities during Phase 1 (no pickleball classes during this initial period). They complete baseline and post-Phase 1 assessments, then begin the same community-based pickleball program during Phase 2 (twice per week for 8 weeks; 16 sessions total). A final post-intervention assessment is completed after the Phase 2 intervention period. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pickleball Program (Community-Based) | Behavioral | Group-based beginner-friendly pickleball classes delivered in community indoor court facilities. Sessions occur twice per week for 8 weeks (16 sessions total), approximately 90 minutes per session, led by trained instructors. |
| Measure | Description | Time Frame |
|---|---|---|
| Sensory-Motor Function (HaptiKart task outcomes) | Sensory-motor integration and proprioceptive bias measured using the HaptiKart videogame task. | T1 (Week 0, enrollment) may occur up to 4 weeks prior to initiation of pickleball intervention; T2 approximately 10 weeks after baseline (up to 12 weeks); T3 approximately 18 weeks after baseline (up to 20 weeks). |
| Autism Symptom Severity (SRS-2 Total Score) | Core autism symptom severity measured by the Social Responsiveness Scale, 2nd edition (SRS-2), adult self-report, total score. The SRS-2 consists of 65 items rated on a 4-point Likert scale (1 = not true; 4 = almost always true). Raw total scores range from 0 to 195. Higher scores indicate greater severity of autism-related social impairment. | T1 (Week 0, enrollment) may occur up to 4 weeks prior to initiation of pickleball intervention; T2 approximately 10 weeks after baseline (up to 12 weeks); T3 approximately 18 weeks after baseline (up to 20 weeks). |
| Measure | Description | Time Frame |
|---|---|---|
| Depression Symptoms (PROMIS Depression) | Self-reported depressive symptoms measured using the Patient-Reported Outcomes Measurement Information System (PROMIS) Emotional Distress-Depression-Short Form. (8-item version). Items are rated on a 5-point Likert scale (1 = never to 5 = always). Raw summed scores range from 8 to 40. Raw scores are converted to standardized PROMIS T-scores (mean = 50, standard deviation = 10) using established scoring tables. Higher T-scores indicate greater depressive symptom severity. T-scores will be used for primary analyses. |
| Measure | Description | Time Frame |
|---|---|---|
| Pickleball Skill Performance | Pickleball performance measured using a structured ball-return assessment with coach fed-ball trials and scored for accuracy and paddle contact quality. | At the first attended pickleball session (initiation of the 8-week intervention) and at the final pickleball session (completion of the 8-week intervention; approximately Week 8). |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Chris Sciammana, MD | Penn State College of Medicine | Principal Investigator |
| Daniel E Lidstone, Ph.D. | Penn State Harrisburg | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Penn State Harrisburg | Recruiting | Middletown | Pennsylvania | 17011 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40531815 | Background | Lidstone DE, Singhala M, Wang LJ, Brown JD, Mostofsky SH. HaptiKart: An engaging videogame reveals elevated proprioceptive bias in individuals with autism spectrum disorder. PLOS Digit Health. 2025 Jun 18;4(6):e0000879. doi: 10.1371/journal.pdig.0000879. eCollection 2025 Jun. |
| Label | URL |
|---|---|
| Related Info | View source |
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| ID | Term |
|---|---|
| D000067877 | Autism Spectrum Disorder |
| D001321 | Autistic Disorder |
| ID | Term |
|---|---|
| D002659 | Child Development Disorders, Pervasive |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
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This study uses a two-arm, parallel-group, delayed-start controlled trial design. Participants are randomized in a 1:1 ratio to either an Early Start intervention group or a Delayed Start group. Randomization is performed separately within each location to maintain balanced group allocation at each site. During Phase 1, the Early Start group participates in the 8-week pickleball intervention while the Delayed Start group continues usual activities. After completion of Phase 1 assessments, the Delayed Start group receives the same intervention during Phase 2. The Early Start group resumes usual activities during Phase 2 and completes an additional follow-up assessment to evaluate whether intervention-related changes are maintained beyond the initial intervention period.
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| T1 (Week 0, enrollment) may occur up to 4 weeks prior to initiation of pickleball intervention; T2 approximately 10 weeks after baseline (up to 12 weeks); T3 approximately 18 weeks after baseline (up to 20 weeks). |
| Sleep-Related Impairment | Self-reported sleep disturbance and sleep-related impairment measured using Patient-Reported Outcomes Measurement Information System (PROMIS) Sleep-Related Impairment - Short Form 8a. The instrument includes 8 items rated on a 5-point Likert scale. Raw summed scores range from 8 to 40. Raw scores are converted to standardized PROMIS T-scores (mean = 50, standard deviation = 10) using published scoring tables. Higher T-scores indicate greater sleep-related impairment (worse daytime functioning related to poor sleep). T-scores will be used for primary analyses. | T1 (Week 0, enrollment) may occur up to 4 weeks prior to initiation of pickleball intervention; T2 approximately 10 weeks after baseline (up to 12 weeks); T3 approximately 18 weeks after baseline (up to 20 weeks). |
| Sleep Disturbance | Sleep disturbance will be measured using the Patient-Reported Outcomes Measurement Information System (PROMIS) Sleep Disturbance-Short Form 8b. The instrument includes 8 items rated on a 5-point Likert scale. Raw summed scores range from 8 to 40. Raw scores are converted to standardized PROMIS T-scores (mean = 50, standard deviation = 10) using published scoring tables. Higher T-scores indicate greater sleep disturbance (worse perceived sleep quality). T-scores will be used for primary analyses. | T1 (Week 0, enrollment) may occur up to 4 weeks prior to initiation of pickleball intervention; T2 approximately 10 weeks after baseline (up to 12 weeks); T3 approximately 18 weeks after baseline (up to 20 weeks). |
| Quality of Life (WHOQOL-BREF) | Quality of life will be measured using the World Health Organization Quality of Life-BREF (WHOQOL-BREF). The WHOQOL-BREF contains 26 items rated on a 5-point Likert scale and yields four domain scores: Physical Health, Psychological Health, Social Relationships, and Environment. Raw domain scores are transformed to a 0-100 scale according to WHO scoring guidelines. Higher scores indicate better quality of life. Domain scores will be analyzed as continuous outcomes. | T1 (Week 0, enrollment) may occur up to 4 weeks prior to initiation of pickleball intervention; T2 approximately 10 weeks after baseline (up to 12 weeks); T3 approximately 18 weeks after baseline (up to 20 weeks). |
| Physical Activity During Sessions (ActiGraph) | Physical activity level during pickleball sessions measured using wearable accelerometry (ActiGraph). | During selected pickleball sessions throughout the 8-week intervention period (Weeks 2, 4, 6, and 8 of the intervention). |