Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Central Adelaide Local Health Network Incorporated | OTHER_GOV |
Not provided
Not provided
Not provided
Not provided
Retrospective cohort study of inpatients at a South Australian tertiary hospital who underwent 18F FDG-PET/CT for investigation of undifferentiated fever or inflammatory syndrome. The aim is to investigate the utility of FDG-PET/CT in the investigation of suspected infection in hospitalised adults. To establish the rate at which FDG-PET/CT contributes to a diagnosis, and how this impacts clinical management and outcomes. From this, to develop further understanding of for which patients this imaging modality contributes meaningfully to outcomes.
A retrospective cohort study of consecutive adult inpatients undergoing 18F-FDG PET/CT for suspected infection or inflammation, excluding infective endocarditis and malignancy-directed scans. Pre-PET variables include inflammatory markers, microbiological results, prior imaging findings and infectious diseases (ID) consultation. PET/CT utility will be adjudicated as diagnostic and/or associated with a change in management using a structured consensus process. Associations between pre-PET factors and clinical utility will be explored using descriptive and logistic analyses.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Infectious diseases consultation |
| ||
| No infectious diseases consultation |
| ||
| Significant pre-PET imaging finding |
| ||
| No significant pre-PET imaging finding |
| ||
| High blood WCC prior to PET |
| ||
| Low WCC prior to PET |
| ||
| High CRP prior to PET |
| ||
| Low CRP prior to PET |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 18F-FDG PET/CT | Diagnostic Test | Nuclear medicine imaging as a diagnostic tool with implication for change in clinical management |
|
| Measure | Description | Time Frame |
|---|---|---|
| Diagnostic yield | • Did PET contribute to diagnostic yield?:
| 30 days |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical change in management | • Clinical change in management: was clinical care altered compared to the documented plan prior to PET? 0 = no, 1 = yes
Examples:
|
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Consecutive adults referred for FDG-PET/CT for evaluation of undifferentiated fever, inflammation or infection.
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Royal Adelaide Hospital | Adelaide | South Australia | 5000 | Australia |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D005335 | Fever of Unknown Origin |
| D005334 | Fever |
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D001832 | Body Temperature Changes |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010335 | Pathologic Processes |
Not provided
Not provided
Not provided
Not provided
Not provided
| 30 days |
| Change in antimicrobial management | •Change in antimicrobial duration/spectrum/therapeutic procedure: this change occurred as a result of PET | 30 days |
| Final diagnosis | • Final diagnosis: infection = 1, non-infectious = 2, malignancy = 3, unresolved = 4 | 30 days |