Identify a Specific Immune Profile in Patients With Chronic Pelvic Pain Resistant to First-line Treatments by Measuring Th1, Th2, Th17, and Treg Cytokines Produced After Non-specific Functional Cell Stimulation - ImmunoCPP

Identify a Specific Immune Profile in Patients With Chronic Pelvic Pain Resistant to First-line Treatments by Measuring Th1, Th2, Th17, and Treg Cytokines Produced After Non-specific Functional Cell Stimulation - ImmunoCPP

Chronic pelvic pain (CPP) affects more than one in four women. An immune imbalance in the Th1/Th2 balance has been reported in multiple CPP situations, particularly in patients with endometriosis, but with mixed results. The use of a functional immune test, already validated in previous indications and particularly in infertility, could simulate an immune stimulation similar to that of painful attacks.

Inclusion Criteria:

1. Aged between 18 and 40;
2. Under continuous hormone treatment for at least 6 months;
3. Imaging less than 12 months old: either normal or showing endometriosis and/or adenomyosis lesions, excluding any other abnormalities that could explain the PCOS;
4. Affiliation with the French Social Security system;
5. Signature of informed consent.

Exclusion Criteria:

1. Pregnant or breastfeeding women;
2. Autoimmune disease;
3. History of cancer within the last 5 years or currently undergoing treatment;
4. Current infectious syndrome;
5. Person under guardianship or conservatorship.