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Dental implants are considered a predictable rehabilitative option following tooth extraction or in cases of missing teeth. In some situations, the inevitable alveolar ridge resorption that occurs after extraction may make the placement of standard-diameter (>3.5 mm) or standard-length implants difficult or even impossible without advanced bone augmentation procedures. To counteract post-extraction volumetric bone contraction, alveolar ridge preservation can be performed, consisting of placing a bone graft within the socket walls immediately after tooth extraction. Although this procedure cannot completely prevent dimensional changes, it has been shown to significantly reduce both horizontal and vertical ridge resorption, as reported in the scientific literature. However, there is a lack of clinical and radiographic studies evaluating the outcomes of implant rehabilitation following alveolar ridge preservation with standard-dimension implants in a hospital-based setting.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Alveolar ridge preservation | Patients aged 18 years and older requiring tooth extraction followed by alveolar ridge preservation to enable implant surgery and prosthetic rehabilitation of edentulous sites. |
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| Measure | Description | Time Frame |
|---|---|---|
| Volumetric analysis | The dimensional change of hard tissues following bone regenerative procedures will be assessed radiographically by measuring horizontal and vertical bone resorption through CBCT comparison in patients treated in a hospital-based setting. | From tooth extraction to 6 months of follow up. |
| Measure | Description | Time Frame |
|---|---|---|
| Esthetic evaluation | Assessed using the PES/WES esthetic index. Scores range from 0 to 14 for the PES and from 0 to 10 for the WES, with higher scores indicating better esthetic outcomes. | From tooth extraction to 5 years of follow-up |
| Implant success rate |
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Inclusion Criteria:
Exclusion Criteria:
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Patients aged 18 years and older requiring bone regeneration with an alveolar ridge preservation technique prior to implant rehabilitation will be included in the study.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Carlo Lajolo, MD, DDS | Contact | 3356078354 | carlo.lajolo@unicatt.it |
| Name | Affiliation | Role |
|---|---|---|
| Carlo Lajolo | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Catholic University of the Sacred Heart | Roma | 00168 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40762250 | Result | Sandoli Arroteia L, Lopes MP, Rea MT, Vieira E Oliveira TR, Oliveira ML, de Faveri M, Santamaria MP, Queiroz LA, Casati MZ, Casarin RCV. Dimensional Changes After Different Alveolar Ridge Preservation Techniques for Posterior Region: A Randomised Controlled Clinical Trial. J Clin Periodontol. 2025 Nov;52(11):1584-1594. doi: 10.1111/jcpe.70004. Epub 2025 Aug 5. | |
| 18546808 |
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Absence of biological and technical complications, expressed as a proportion |
| From tooth extraction to 5 years of follow up |
| Implant survival rate | Rate of dental implants remaining in situ, measured as a proportion | From tooth extraction to 5 years follow up |
| Prosthesis success rate | Absence of technical complications, expressed as a proportion | From tooth extraction to 5 years of follow up |
| Prosthesis survival rate | Rate of prostheses remaining in situ, expressed as a proportion | From tooth extraction to 5 years of follow up |
| Patient-Reported Outcome Measures | Recorded using a specifically designed questionnaire and measured with a visual analogue scale (VAS) ranging from 0 to 10, with higher scores indicating better outcomes | From tooth extraction to 5 years of follow up |
| Diabetes | Analysis of the influence of diabetes (assessed as presence/absence) as potential risk factor during follow-up | From tooth extraction to 5 years of follow up |
| Glycated hemoglobin level | Analysis of glycated hemoglobin levels recorded at baseline and during follow-up | From tooth extraction to 5 years of follow up |
| Correlation of medications relevant to bone/soft tissue metabolism with implant health | Correlation between exposure to medications affecting bone and soft tissue metabolism and peri-implant marginal bone loss (measured in millimeters on standardized periapical radiographs) and implant success (defined as the absence of complications). | From tooth extraction to 5 years of follow up |
| Correlation between osteoporosis status and implant health | Correlation between osteoporosis status (DXA T-score/ICD diagnosis) and peri-implant marginal bone loss (measured in millimeters on standardized periapical radiographs) and implant success (defined as the absence of complications). | From tooth extraction to 5 years of follow up |
| Correlation between cardiovascular disease and implant health | Correlation between cardiovascular diseases and peri-implant marginal bone loss (measured in millimeters on standardized periapical radiographs) and implant success (defined as the absence of complications). | From tooth extraction to 5 years of follow up |
| Complete Blood Count | Analysis of the influence of complete blood count parameters | From tooth extraaction to 5 years of follow up |
| Histologic analysis | Histomorphometric analysis of hard and soft tissues on stained histologic sections (% new bone, residual graft, epithelial thickness, keratin layer thickness, inflammatory infiltrate, collagen organization, and vascular density) | From tooth extraction to 6 months of follow up |
| Araujo M, Linder E, Wennstrom J, Lindhe J. The influence of Bio-Oss Collagen on healing of an extraction socket: an experimental study in the dog. Int J Periodontics Restorative Dent. 2008 Apr;28(2):123-35. |
| 15691354 | Result | Araujo MG, Lindhe J. Dimensional ridge alterations following tooth extraction. An experimental study in the dog. J Clin Periodontol. 2005 Feb;32(2):212-8. doi: 10.1111/j.1600-051X.2005.00642.x. |