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in this study we evaluated the effectiveness and safety of corneal collagen cross-linking in keratoconic eyes with thin cornea after induction of stromal emphysema prior to riboflavin instillation and UV-A corneal irradiation
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with progressive keratoconus | Other |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Corneal collagen cross-linking with induction of corneal stromal emphysema | Procedure | Corneal collagen cross-linking with induction of corneal stromal emphysema |
|
| Measure | Description | Time Frame |
|---|---|---|
| Evaluating effectiveness of Cross-linking in the presence of air in corneal stroma | Through serial corneal tomography | Corneal tomography will be performed preoperatively then 6, and 12 months after the procedure |
| Assessment of the safety of this procedure on corneal endothelial cells | By evaluating corneal endothelium structural integrity, using serial specular microscopy imaging | Specular microscopy will be performed preoperatively, then 1, 3 and 6 months after the procedure |
| Measuring demarcation line depth in microns from corneal epithelium | both reflectivity and depth (in microns) of demarcation line will be evaluated by using corneal OCT | one month after procedure |
| Measure | Description | Time Frame |
|---|---|---|
| To detect changes in the visual acuity (in decimal) | Preoperative and postoperative examinations will be carried out for visual acuity, using Snellen visual acuity chart. | preoperatively then 1 week and 1, 3, 6, and 12 months after the procedure. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Ophthalmology-Faculty of Medicine-Cairo University | Giza | Giza Governorate | 11562 | Egypt |
The datasets used and/or analyzed during this study are available from the principal investigator on reasonable request.
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| ID | Term |
|---|---|
| D007640 | Keratoconus |
| ID | Term |
|---|---|
| D003316 | Corneal Diseases |
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| D000094504 | Corneal Cross-Linking |
| ID | Term |
|---|---|
| D010778 | Photochemotherapy |
| D003131 | Combined Modality Therapy |
| D013812 | Therapeutics |
| D004358 | Drug Therapy |
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prospective, interventional, case series
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| D010789 |
| Phototherapy |