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Cesarean section is one of the commonly performed surgical procedures in the world. Once baby is delivered during the surgical procedure anesthesiologist administer Oxytocin drug through IV cannula which helps the Uterus to contract so that excessive blood loss doesnt occur. But this is associated with fall in blood pressure frequently requiring administration of medications to treat low blood pressure. The most frequently used drug is phenylephrine which can administered along with oxytocin to prevent fall in blood pressure. This study will compare to different doses of Phenylephrine to prevent fall in blood pressure.
Cesarean section is one of the most commonly performed surgical procedures worldwide. Following delivery of the neonate, oxytocin is routinely administered intravenously to promote uterine contraction and thereby reduce the risk of postpartum hemorrhage. However, oxytocin administration is frequently associated with maternal hypotension, which may necessitate pharmacological intervention. Phenylephrine, a selective α-adrenergic agonist, is commonly used to prevent or treat oxytocin-induced hypotension due to its vasoconstrictive properties. The optimal prophylactic dose of phenylephrine administered concurrently with oxytocin remains uncertain. This study aims to compare two different doses of phenylephrine for the prevention of hypotension following oxytocin administration during cesarean section.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Phenylephrine 75 | Active Comparator |
| |
| Phenylephrine 50 | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Phenylephrine bolus 75 micrograms | Drug | After delivery of Baby during C section, patient will be administered 3 IU of Oxytocin over 3 minutes along with 75 micrograms of Phenylephrine Intravenously. |
| Measure | Description | Time Frame |
|---|---|---|
| Number of Hypotensive episodes | Hypotension will be defined as fall in Mean Arterial pressure by more than 20% from baseline value. | Number of hypotensive episodes occuring upto 10 minutes after administration of Oxytocin and Phenylephrine |
| Measure | Description | Time Frame |
|---|---|---|
| Rescue Phenylephrine consumed | This will be the total amount of Phenylephrine consumed to treat the hypotensive episodes occuring upto 10 minutes after administration of Oxytocin and Phenylephrine |
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Inclusion Criteria:
- Females having a singleton pregnancy Patients planned for elective cesarean section under spinal anesthesia
Exclusion Criteria:
Patients having a placental abnormality
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Farwa Javed Principal Investigator, MBBS | Contact | +92 304 8954091 | farwajaved44@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Jawad Zahir | Head of Department of Anesthesia | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesia, Holy Family Hospital, Rawalpindi | Recruiting | Rawalpindi | Punjab Province | 46000 | Pakistan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Background | Sharma N, Agarwal S, Modi YC, Yadav A, Yadav J, Sindhi R, et al. Effect of Two Different Doses of Intravenous Phenylephrine on the Prevention of Oxytocin Induced Hypotension in Lower Segment Caesarean Section Under Subarachnoid Block: A Randomised Controlled Study. J Clin Diagn Res. 2023;17(9):16-21. |
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It is not allowed by Hospital Ethical Committee
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| Phenylephrine bolus 50 micrograms | Drug | After delivery of Baby during C section, patient will be administered 3 IU of Oxytocin over 3 minutes along with 50 micrograms of Phenylephrine Intravenously. |
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