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Necrotising soft-tissue infections (NSTIs) are rare and life-threatening skin and soft tissue infections requiring urgent combined medical and surgical management in specialist centres. At Assistance Publique-Hôpitaux de Paris, a multidisciplinary reference network called the SURFAST consortium has been established. This network includes experts in the management of NSTIs, such as intensivists, dermatologists, infectious disease physicians, paediatricians, surgeons, and microbiologists. The consortium manages all NSTI cases referred from the greater Paris area, a large region of France with a population exceeding 12 million.
The SURFAST network comprises care pathways enabling the management of adult and paediatric patients with abdomino-perineal, limb, and cervico-facial NSTIs. All patients managed within this care pathway are included in a prospective, multicentre cohort study. This study examines factors associated with mortality at day 90, long-term sequelae, quality of life, and indicators of the quality of care.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| - Adult / limb and abdomino-perineal | |||
| - Adult / cervico-facial | |||
| - Pediatric |
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| Measure | Description | Time Frame |
|---|---|---|
| mortality | If the patient is still hospitalized, an on-site visit will be conducted; otherwise, the patient or their relative will be contacted by telephone by an investigator or a study coordinator | 90 days |
| Measure | Description | Time Frame |
|---|---|---|
| hospital mortality | vital status measured at hospital discharge | at hospital discharge and within 60 days of hospital admission |
| time from hospital admission to first surgical debridement | time period measured in hours between first hospital admission and first surgical debridement |
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Inclusion Criteria:
Exclusion Criteria:
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Patients (adults and children) with a suspected or confirmed necrotizing soft-tissue infections (NSTI) managed within the SURFAST care pathway.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Nicolas DE PROST, PU-PH | Contact | +33 1 45 17 86 37 | nicolas.de-prost@aphp.fr | |
| thomas URBINA, Dr | Contact | Tomas.urbina@aphp.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Henri Mondor, 1 rue Gustave Eiffel, | Créteil | Île-de-France Region | 94000 | France |
DATAS ARE OWN BY ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS, PLEASE CONTACT SPONSOR FOR FURTHER INFORMATION
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| ID | Term |
|---|---|
| D019115 | Fasciitis, Necrotizing |
| ID | Term |
|---|---|
| D005208 | Fasciitis |
| D009140 | Musculoskeletal Diseases |
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Plasma, serum, Tissue, RNA
| within the first 72 hours of hospital admission |
| functional outcome and quality of life | measured using the Activity of Daily Living (ADL) and the EQ-5D-5L (EuroQol) French version scores | day 90 post-admission |
| amputation rate | toe or limb amputation performed | day 90 |
| annual case volume per centre | number of NSTI cases managed per year in each centre participating in the SURFAST network | 123 months |
| bacteriological documentation | bacterial documentation of NSTIs obtained from blood cultures or cultures of operative tissue samples. | At the time of blood culture collection or operative tissue sampling |