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This multicenter prospective observational study will evaluate the value of dynamic FDG-PET LAFOV imaging during the initial therapeutic assessment of a head and neck cancer 3 months after completion of curative radiotherapy.
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| Measure | Description | Time Frame |
|---|---|---|
| Parameters obtained using the Patlak Direct IDIF reconstruction method, Ki mean, Ki max, DV mean and DV max (standards) in FDG-PET LAFOV in the residual disease and post-treatment inflammation groups | The reference test for the diagnosis of " residual diseases " and " post-radiation inflammation" will be based on the conclusion of the multidisciplinary team meeting ruling on the results of composite data, including clinical examination, pathological examination, morphological imaging (CT or MRI) and/or functional imaging (early evaluation PET). The index test will be based on FDG-PET LAFOV whose parameters obtained using the Patlak Direct IDIF, Ki mean, Ki max, DV mean and DV max (standards) in the residual disease and post-therapy inflammation groups. | 3 months post-curative radiotherapy |
| Measure | Description | Time Frame |
|---|---|---|
| Standard Ki and DV parameters in LAFOV FDG-PET and anatomical pathology characteristics of tumours (p16 status, CPS, degree of tumour differentiation). | 3 months post-curative radiotherapy | |
| Dynamic (standard Ki and DV) and static (SUVmax, SUVmean, SUVpeak, MTV, TLG, textural features) parameters in LAFOV FDG-PET. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients treated with radiotherapy for curative purposes for squamous cell carcinoma of the upper aerodigestive tract.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ronan ABGRAL, Pr | Contact | +332 98 22 30 69 | ronan.abgral@chu-brest.fr | |
| Jean-Christophe LECLERE, Dr | Contact | +332 98 22 02 91 | jean-christophe.leclere@chu-brest.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Brest | Recruiting | Brest | 29200 | France |
All collected data that underlie results in a publication
Data will be available beginning two years and ending five years following the publication
Data access requests will be reviewed by the internal committee of Brest UH. Requestors will be required to sign and complete a data access agreement.
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| 3 months post-curative radiotherapy |
| Ki and DV parameters in LAFOV FDG-PET and the occurrence of post-radiation toxicity | 3 months post-curative radiotherapy |
| DV and Ki parameters derived from direct and indirect Patlak reconstructions with IDIF and/or PBIF. | 3 months post-curative radiotherapy |
| Dates of imaging, dates of progression, dates of death and end of study dates | 12 months post TEP-FDG LAVOF imaging |
| ID | Term |
|---|---|
| D000077195 | Squamous Cell Carcinoma of Head and Neck |
| D002294 | Carcinoma, Squamous Cell |
| ID | Term |
|---|---|
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D006258 | Head and Neck Neoplasms |
| D009371 | Neoplasms by Site |
| D018307 | Neoplasms, Squamous Cell |
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