Diagnostic Performance Of 4D Dynamic LAFOV FDG-PET Acquisition for Differentiation of Residual Disease and Post-radiation Inflammation in Head Neck SCC Treated by Radiotherapy.

ClinicalTrials.gov ID

NCT07417605

Lead Sponsor

University Hospital, BrestOTHER

Overall Status

Recruiting

Study Type

Observational

Enrollment

180Estimated

Last Update Posted

Jul 13, 2026Actual

Start Date

Apr 13, 2026Actual

Primary Completion Date

Jun 13, 2029Estimated

Completion Date

Jun 13, 2029Estimated

Official Title

Diagnostic Performance Of 4D Dynamic LAFOV FDG-PET Acquisition for Differentiation of Residual Disease and Post-radiation Inflammation in Head Neck SCC Treated by Radiotherapy.

Brief Summary

This multicenter prospective observational study will evaluate the value of dynamic FDG-PET LAFOV imaging during the initial therapeutic assessment of a head and neck cancer 3 months after completion of curative radiotherapy.

• Head & Neck Squamous Cell Carcinoma

Ages Eligible for Study

Adult (18-64)Older Adult (65+)

Sexes Eligible for Study

All

Accepts Healthy Volunteers

No

Eligibility Criteria

Inclusion Criteria:

• Adult patient ≥ 18 years of age
• Presenting with head and neck squamous cell carcinoma
• Completed curative treatment with external radiation therapy
• Eligible for dynamic LAFOV FDG-PET scan for therapeutic evaluation at 3 months
• Having given consent for the end-of-treatment consultation

Exclusion Criteria:

• Hypersensitivity to 18F-FDG or other excipients contained in the contrast agent
• Pregnancy or breastfeeding
• History of treated upper gastrointestinal tract cancer
• Other histology
• Incomplete RTE treatment regimen
• Refusal to participate

Observational Model

Cohort

Time Perspective

Prospective

Lead Sponsor

University Hospital, BrestOTHER

jean-christophe.leclere@chu-brest.fr+33229020291

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