Virtual hIStology of Crohn's Disease Ex-vivo Resected Anatomical Lesions

Virtual hIStology of Crohn's Disease Ex-vivo Resected Anatomical Lesions

Crohn's disease is a chronic, incurable inflammatory bowel disease with an unpredictable course, characterized by alternating remission and inflammatory flares. Current follow-up strategies are poorly suited to early flare detection, leading to uncontrolled disease progression and complications. A major clinical challenge is distinguishing reversible inflammatory activity from irreversible intestinal fibrosis, as existing imaging techniques lack specificity. This study aims to perform comprehensive ex vivo multiparametric MRI, combined with biophysical measurements and histopathology, on resected intestinal specimens to precisely map inflammation and fibrosis and to validate in vivo MRI-derived biomarkers for personalized therapeutic decision-making.

Inclusion Criteria:

• Age ≥ 18 years.
• Diagnosis of Crohn's disease and undergoing intestinal resection surgery at CHRU Nancy.
• Patient has not objected to the reuse of personal data and biological samples for the purposes of this research.

Exclusion Criteria:

- None